alpha-2-HS-Glycoprotein (AHSG) antibody

Antigen: alpha-2-HS-Glycoprotein (AHSG)

Synonyms: AHS, A2HS, HSGA, FETUA, fetuin-A, pp63, Aa2-066, AHSG, ahs, a2hs, hsga, fetua, MGC103687, MGC192819, wu:fb63g02, zgc:103687, MGC116429, Ahsg

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Western Blotting (WB)

Catalog no.: ABIN115504

Additional Information

Characteristics: Synonyms: Fetuin A, AHSG, FETUA, PRO2743, Ba-alpha-2-glycoprotein, Alpha-2-Z-globulin

Alternative name: Alpha-2-HS-glycoprotein

Swiss-Prot: P02765

Immunogen: Human serum

Description: Fetuin-A (AHSG), a 59 kDa glycoprotein, consisting of two cystatin-like domains and asmaller unrelated domain, is predominantly sinthetized in liver . It is secreted into theblood stream and deposited as a noncollagenous protein in mineralized bones and teeth. Fetuin-A occurs in high serum concentrations during foetal life, whereas its level declinesfollowing infection, inflamatory and malignancy. Fetuin-A acts as an important circulatinginhibitor of ectopic calcification, frequent complication of many degenerative diseases. Low serum level of Fetuin-A is associated with vascular and valvular calcification,atherosclerosis, malnutrition and higher cardiovascular mortality in chronic renal failure,liver cancer and liver cirrhosis patients on long-term dialysis. AHSG protein represents anatural inhibitor of tyrosinase kinase activity of the insulin receptor. It may play asignificant role in regulating postprandial glucose disposal, insulin sensitivity, weightgain, and fat accumulation. The serum and bone-resident Fetuin-A binds to transforminggrowth factor- beta and blocks TGFbeta binding to cell surface receptors.

Specificity: This antibody reacts to Fetuin-A. Species: Human. Others not tested.

Application Details

Application Notes: ELISA. Western Blot. Immunohistochemistry on frozen sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Concentration: 1.0 mg/ml

Buffer: 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREEReconstitution: Restore with 0.1 ml of deionized water

Storage: Store lyophilized (preferably in a desiccator) at -20°C and in aliquots at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time, it does not showdecline in activity after two weeks at 4°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.

Research Area: Immunology, Inflammation, Serum/Plasma Proteins

Restrictions: For Research Use only