alpha-2-HS-Glycoprotein (AHSG) antibody

Details for Product No. ABIN115504
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Antigen
Synonyms ahs, a2hs, hsga, fetua, wu:fb63g02, zgc:103687, AHSG, MGC116429, A2HS, AHS, FETUA, HSGA, Aa2-066, pp63
Reactivity
Human
(85), (19), (19), (16), (13)
Host
Rabbit
(55), (17), (13), (9), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Western Blotting (WB)
(70), (57), (24), (18), (14), (12), (10), (8), (7), (5), (3), (2), (2), (1), (1), (1), (1)
Pubmed 6 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN115504
533.50 $
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Immunogen Human serum
Specificity This antibody reacts to Fetuin-A.
Purification Immunoaffinity chromatography
Alternative Name Alpha-2-HS-glycoprotein
Background Fetuin-A (AHSG), a 59 kDa glycoprotein, consisting of two cystatin-like domains and a smaller unrelated domain, is predominantly sinthetized in liver . It is secreted into the blood stream and deposited as a noncollagenous protein in mineralized bones and teeth. Fetuin-A occurs in high serum concentrations during foetal life, whereas its level declines following infection, inflamatory and malignancy. Fetuin-A acts as an important circulating inhibitor of ectopic calcification, frequent complication of many degenerative diseases. Low serum level of Fetuin-A is associated with vascular and valvular calcification, atherosclerosis, malnutrition and higher cardiovascular mortality in chronic renal failure, liver cancer and liver cirrhosis patients on long-term dialysis. AHSG protein represents a natural inhibitor of tyrosinase kinase activity of the insulin receptor. It may play a significant role in regulating postprandial glucose disposal, insulin sensitivity, weight gain, and fat accumulation. The serum and bone-resident Fetuin-A binds to transforming growth factor- beta and blocks TGFbeta binding to cell surface receptors.
Alternate names: AHSG, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, FETUA, Fetuin A, PRO2743
Gene ID 197
NCBI Accession NP_001613
UniProt P02765
Research Area Immunology, Inflammation, Serum/Plasma Proteins
Application Notes ELISA. Western Blot. Immunohistochemistry on frozen sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 0.1 mL of deionized water
Concentration 1.0 mg/mL
Buffer 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Prior to reconstitution store at -70°C. Following reconstitution store the antibody (in aliquots) at -20°C for 6 months.
Expiry Date 6 months
Background publications Arnaud, Kalabay: "Alpha2-HS glycoprotein: a protein in search of a function." in: Diabetes/metabolism research and reviews, Vol. 18, Issue 4, pp. 311-4, 2002 (PubMed).

Ketteler, Bongartz, Westenfeld et al.: "Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional study." in: Lancet, Vol. 361, Issue 9360, pp. 827-33, 2003 (PubMed).

Jersmann, Dransfield, Hart: "Fetuin/alpha2-HS glycoprotein enhances phagocytosis of apoptotic cells and macropinocytosis by human macrophages." in: Clinical science (London, England : 1979), Vol. 105, Issue 3, pp. 273-8, 2003 (PubMed).

Schafer, Heiss, Schwarz et al.: "The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification." in: The Journal of clinical investigation, Vol. 112, Issue 3, pp. 357-66, 2003 (PubMed).

Denecke, Gräber, Schäfer et al.: "Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A." in: The Biochemical journal, Vol. 376, Issue Pt 1, pp. 135-45, 2003 (PubMed).

Ketteler, Gross, Ritz: "Calcification and cardiovascular problems in renal failure." in: Kidney international. Supplement, Issue 94, pp. S120-7, 2005 (PubMed).

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