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Myostatin (MSTN) antibody

Details for Product No. ABIN115510
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Antigen
Synonyms GDF-8, GDF8, gdf8, mstn, zgc:109749, Gdf8, NV13143, MSLHP, Cmpt
Reactivity
Human
(122), (52), (43), (41), (36), (24), (12)
Host
Chicken
(82), (27), (26), (6), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (7), (5), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
ELISA
(93), (71), (35), (30), (28), (10), (8), (2), (1)
Pubmed 4 references available
Quantity 50 µg
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Catalog No. ABIN115510
412.50 $
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Immunogen Recombinant human myostatin propeptide from E. coli.
Sequence Total 248 AA. MW: 28 kDa (calculated). 243 AA of recombinant human Myostatin Propeptide and 5 extra AA: MGNENSEQKE NVEKEGLCNA CTWRQNTKSS RIEAIKIQIL SKLRLETAPN ISKDVIRQLL PKAPPLRELI DQYDVQRDDS SDGSLEDDDY HATTETIITM PTESDFLMQV DGKPKCCFFK FSSKIQYNKV VKAQLWIYLR PVETPTTVFV QILRLIKPMK DGTRYTGIRS LKLDMNPGTG IWQSIDVKTV LQNWLKQPES NLGIEIKALD ENGHDLAVTF PGPGEDGLNP FLEVKVTDTP KRSRRKLN Remarks: The amino acid sequence of the recombinant Human Myostatin Propeptide is 100% homologous with the amino acid sequence of the Human Myostatin Propeptide without signaling sequence.
Specificity The recombinant human myostatin propeptide is 100% homologous with the human serum myostatin propeptide.
Purification Immunoaffinity chromatography.
Alternative Name Myostatin
Background Myostatin (GDF-8), a member of the TGFbeta superfamily, is a potent and specific negative regulator of skeletal muscle mass. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.
Alternate names: GDF-8, GDF8, Growth differentiation factor 8, MSTN
Gene ID 2660
NCBI Accession NP_005250.1
UniProt O14793
Research Area Hormones
Application Notes Suitable for ELISA: Titer is defined by indirect ELISA, it is: > 1/100,000 for antibodyconcentration 1 mg/ml, 25 ng of antigen are coated per well, and is then defined at a pointof maximal decrease of the titration curve. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.05 mL of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
Concentration 1.0 mg/mL
Buffer 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2 containing no preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing. Dilute only prior to immediate use.
Storage -20 °C
Storage Comment Store (in aliquots) at -20° C or below.
Expiry Date 12 months
Background publications Hill, Davies, Pearson et al.: "The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40735-41, 2002 (PubMed).

Hill, Qiu, Hewick et al.: "Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains." in: Molecular endocrinology (Baltimore, Md.), Vol. 17, Issue 6, pp. 1144-54, 2003 (PubMed).

Wolfman, McPherron, Pappano et al.: "Activation of latent myostatin by the BMP-1/tolloid family of metalloproteinases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 26, pp. 15842-6, 2003 (PubMed).

Kawano, Blakely, Gordon et al.: "Theory of dielectric micro-sphere dynamics in a dual-beam optical trap." in: Optics express, Vol. 16, Issue 13, pp. 9306-17, 2008 (PubMed).

Validation Images
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