Inhibitor of Growth Family, Member 4 (ING4) (Isoform 1), (AA 164-175) antibody

Details for Product No. ABIN118054
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Antigen
Synonyms wu:fb11d09, wu:fb50e02, zgc:110619, ING4, my036, p29ING4, D6Wsu147e, D6Xrf92
Epitope
Isoform 1, AA 164-175
(5), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Chicken, Human, Monkey, Mouse (Murine), Rat (Rattus)
(39), (23), (18), (4), (2), (2), (2)
Host
Goat
(31), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(29), (16), (10), (9), (4), (3), (3), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN118054
390.50 $
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Immunogen A synthetic peptide corresponding aa 164-175 of Human p29 ING4 protein. This sequence only shows homology to isoform 1 for ING4. Genename: ING4
Sequence Protein sequence for Human p29 ING4 isoform 1, 249 aa, predicted MW 28.5 kDa: 1 maagmylehy ldsienlpfe lqrnfqlmrd ldqrtedlka eidklateym ssarslssee 61 klallkqiqe aygkckefgd dkvqlamqty emvdkhirrl dtdlarfead lkekqiessd 121 ydsssskgkk kgrtqkekka ararskgkns deeapktaqk klklvrtspe ygmpsvtfgs 181 vhpsdvldmp vdpneptycl chqvsygemi gcdnpdcsie wfhfacvglt tkprgkwfcp 241 rcsqerkkk Protein sequence for Human p29 ING4 isoform 2, 47 aa, predicted MW 5.6 kDa: 1 maagmylehy ldsienlpfe lqrnfqlmrd ldqrteeald tissleh
Specificity Reactivity occurs against human p29 ING4 protein. 100 % homology is on record for this protein from human, dog, rat, and mouse. Cross reactivity with p29 ING4 protein from chimpanzee and chicken sources is also expected based on high homology (one amino acid change in sequence) by BLAST. Reactivity with p29 ING4 proteins from other sources is not known.
Purification Immunoaffinity chromatography.
Alternative Name ING4
Background P29 ING4 is a tumor suppressor protein similar to ING1 that may inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. p29 ING4 has been shown to suppress brain tumor angio-genesis through transcriptional repression of RelA/ NFKB3 target genes when complexed with RelA. p29 ING4 may also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. p29 ING4 shows a nuclear localization and interacts with EP300, TP53, RelA, inhibits cell growth, and induces apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. Multiple alternatively spliced transcript variants have been observed. The accession number listed below is for variant (1) that encodes the longest isoform.Synonyms: Inhibitor of growth protein 4, My036, p29ING4
Gene ID 51147
NCBI Accession NP_001121054
UniProt Q9UNL4
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Antibody R1606P has been tested for use in ELISA (1: 3,000-1: 12,000) against theimmunizing peptide. Specific conditions for Western blotting (1: 500-1: 3,000) reactivity
Restrictions For Research Use only
Concentration 1.28 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, containing 0.01 % (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice This product is photosensitive and should be protected from light
Storage 4 °C
Storage Comment Store undiluted at 2-8 °C. DO NOT FREEZE!
Supplier Images
anti-Inhibitor of Growth Family, Member 4 (ING4) (Isoform 1), (AA 164-175) antibody Figure shows the structural features of the inhibitor of growth (ING) protein family members. Panel A shows the four isoforms of ING1 generated by alternative splicing. Panel C shows four additional ING proteins 2-5 that also contain similar motifs, namely, PHD domains, NLS motifs, and, for ING2, a leucine zipper domain which promotes protein int
General Yuasa, Nagayama, Suzuki et al.: "[Sertoli cell tumor of the testis: a case report]" in: Hinyokika kiyo. Acta urologica Japonica, Vol. 45, Issue 7, pp. 501-4, 1999 (PubMed).

Garkavtsev, Kozin, Chernova et al.: "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis." in: Nature, Vol. 428, Issue 6980, pp. 328-32, 2004 (PubMed).

Wang, He, Wang et al.: "[Impact of Donor KIR2DS5 Genotype on Outcome Following Haploidentical Hematopoietic Stem Cell Transplantation.]" in: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, Vol. 16, Issue 1, pp. 111-5, 2008 (PubMed).

Kim, Choi, Park et al.: "Endometrial stromal sarcoma of the small bowel: a case report and review of literature." in: Annals of diagnostic pathology, Vol. 12, Issue 2, pp. 128-33, 2008 (PubMed).

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