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Integrin alpha 1 (ITGA1) antibody (FITC)

Details for Product No. ABIN118691
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Antigen
Synonyms CD49A, E130012M19Rik, Vla1, CD49a, VLA1
Reactivity
Human
(66), (23), (23), (12), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Host
Mouse
(40), (31), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
(7), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(36), (25), (23), (15), (15), (14), (10), (8), (6), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN118691
412.50 $
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Clone TS2-7
Isotype IgG1
Specificity This antibody recognises the alpha 1 integrin subunit, which forms the VLA-1 heterodimer in association with the beta 1 integrin.
Purification Affinity Chromatography on Protein G.
Alternative Name CD49a / ITGA1
Background Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Alpha 1 integrin along with alpha 2, alpha L and alpha M has a unique inserted domain. Integrin alpha 1 is a receptor for laminin and collagen. The alpha1 subunit is also known as CD49a. CD49a associates with CD29 (beta 1 integrin), to form an alpha1 beta1 heterodimer, identified as the rat homologue to VLA1, which is involved in cellular adhesion to laminin and collagen.
Alternate names: CD49 antigen-like family member A, ITGA-1, Integrin alpha-1, Laminin and Collagen Receptor, VLA-1, VLA1
Gene ID 3672
NCBI Accession NP_852478.1
UniProt P56199
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry: Neat-1/5, Use 10ul of the suggested working dilution to label 10e6 cells in 100ul. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Integrin alpha 1 (ITGA1) antibody (FITC) Staining of HeLa cells with MOUSE ANTI HUMAN CD49a:FITC (ABIN118691).
Background publications Hemler, Jacobson, Strominger: "Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cells." in: The Journal of biological chemistry, Vol. 260, Issue 28, pp. 15246-52, 1986 (PubMed).

Hafler, Hemler, Christenson et al.: "Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases." in: Clinical immunology and immunopathology, Vol. 37, Issue 2, pp. 163-71, 1985 (PubMed).

Hemler, Sanchez-Madrid, Flotte et al.: "Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 132, Issue 6, pp. 3011-8, 1984 (PubMed).

Validation Images
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