CD51/CD61 Complex antibody

Details for Product No. ABIN118722
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Antigen
Reactivity
Chicken, Human
(3), (3)
Host
Mouse
(3)
Clonality (Clone)
Monoclonal ()
Application
Immunoprecipitation (IP), Flow Cytometry (FACS)
(3), (3), (1)
Pubmed 1 reference available
Catalog no. ABIN118722
Quantity 0.2 mg
Price
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Immunogen Osteoclasts from osteoclastomas. Spleen cells from immunised mice were fused with cells of the mouse X63.Ag8.653 myeloma cell line.
Clone 23C6
Isotype IgG1
Specificity This antibody recognises the intact complex formed between the CD51 and CD61 molecules (alpha V and beta 3 integrins). This complex binds vitronectin at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. 23C6 reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.
Purification Affinity chromatography on Protein A
Background Alternate names: CD51, CD61, GP3A, GPIIIa, ITGAV, ITGB-3, ITGB3, Integrin alpha-V, Integrin beta-3, MSK8, Platelet membrane glycoprotein IIIa, VNRA, Vitronectin Receptor, Vitronectin receptor subunit alpha
NCBI Accession 9606
UniProt P06756
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: 1/40 - 1/80, Use 10ul of the suggested working dilution to label 10e6 cells in 100ul. Immunoprecipitation. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH7.4 containing 0.09% Sodium Azide
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Horton, Lewis, McNulty et al.: "Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens." in: Cancer research, Vol. 45, Issue 11 Pt 2, pp. 5663-9, 1985 (PubMed).

Hosts (3)
Reactivities (3), (3)
Applications (3), (3), (1)
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