Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody (Biotin)

Details for Product No. ABIN119125
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Antigen
Synonyms CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, C85791, Cd31, Pecam
Reactivity
Human
(389), (187), (68), (41), (30), (20), (11), (5), (2), (1)
Host
Mouse
(291), (163), (81), (4), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
(59), (45), (31), (18), (10), (5), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(298), (198), (125), (118), (103), (76), (63), (56), (41), (20), (20), (10), (5), (4), (2), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN119125
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Clone WM59
Isotype IgG1
Specificity This antibody recognises the CD31 cell surface antigen. .
Purification Affinity chromatography on Protein G.
Alternative Name CD31 / PECAM1
Background CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is constitutively expressed on the surface of endothelial cells, and concentrated at the junction between them. It is also weakly expressed on many peripheral lymphoid cells and platelets. CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas). CD31 is a 130kD glycoprotein expressed by platelets, endothelial cells, granulocytes and some lymphocytes
Alternate names: EndoCAM, GPIIA', PECAM-1, Platelet endothelial cell adhesion molecule
Gene ID 9606
UniProt P16284
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: Use 10 ul of neat-1/10 diluted antibody to label 10e6 cells in 100 ul. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody (Biotin) Staining of human peripheral blood platelets with MOUSE ANTI HUMAN CD31:BIOTIN (ABIN119125).
Background publications Stockinger, Gadd, Eher et al.: "Molecular characterization and functional analysis of the leukocyte surface protein CD31." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 11, pp. 3889-97, 1991 (PubMed).

Cabañas, Sanchez-Madrid, Bellon et al.: "Characterization of a novel myeloid antigen regulated during differentiation of monocytic cells." in: European journal of immunology, Vol. 19, Issue 8, pp. 1373-8, 1989 (PubMed).

DeLisser, Newman, Albelda: "Molecular and functional aspects of PECAM-1/CD31." in: Immunology today, Vol. 15, Issue 10, pp. 490-5, 1994 (PubMed).

Yoshino, Ami, Terao et al.: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).

Urquhart, Rosignoli, Cooper et al.: "Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow." in: The Journal of pharmacology and experimental therapeutics, Vol. 321, Issue 2, pp. 656-62, 2007 (PubMed).

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