Bone Morphogenetic Protein 7 (BMP7) (AA 293-431) antibody

Details for Product No. ABIN121162
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Antigen
Synonyms OP-1, OP1, bmp7, fb83f09, wu:fb83f09, BMP-7, bmp-7, op-1, BMP7, zgc:153025
Epitope
AA 293-431
(10), (4), (4), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(127), (40), (39), (13), (13), (13), (13), (1), (1)
Host
Mouse
(84), (44), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(97), (73), (23), (19), (10), (7), (6), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1)
Pubmed 4 references available
Catalog no. ABIN121162
Quantity 0.1 mL
Price
412.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Recombinant human BMP7 (293-431 aa) purified from E. coli
Clone 4E7
Isotype IgG1
Purification Protein-G affinity chromatography
Alternative Name BMP7
Background BMP-7 (bone morphogenetic protein-7), also known as OP-1 (osteogenic protein-1), is a member of the transforming growth factor b (TGF b ) superfamily. BMP-7 plays an essential role during ontogeny of the mammalian eye and kidney, also, is expressed in heart, lung, small intestine, limb bud and teeth. In addition, noggin, one of the soluble BMP antagonists, regulated the action of BMPs on mesenchymal precursor cells, partially through a feedback type of inhibition. Alternate Names: BMP-7, OP1, OP-1, Bone morphogenetic protein 7, Osteogenic protein 1, Eptotermin alfa (INN).
UniProt P18075
Research Area Organogenesis, Cell Cycle, Extracellular Matrix, Signaling, Hormones, Cytokines
Application Notes ELISA. Western blot (1/500 - 1/1,000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, containing 0.09 % Sodium Azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Bone Morphogenetic Protein 7 (BMP7) (AA 293-431) antibody Western blot analysis.,.The extracts of mouse kidney (MK) and rat heart (RH) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP7 antibody (1:1,000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
General Sampath, Coughlin, Whetstone et al.: "Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily." in: The Journal of biological chemistry, Vol. 265, Issue 22, pp. 13198-205, 1990 (PubMed).

Godin, Takaesu, Robertson et al.: "Regulation of BMP7 expression during kidney development." in: Development (Cambridge, England), Vol. 125, Issue 17, pp. 3473-82, 1998 (PubMed).

Groppe, Greenwald, Wiater et al.: "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin." in: Nature, Vol. 420, Issue 6916, pp. 636-42, 2002 (PubMed).

Gregory, Ono, Charbonneau et al.: "The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix." in: The Journal of biological chemistry, Vol. 280, Issue 30, pp. 27970-80, 2005 (PubMed).

Hosts (84), (44), (3), (2)
Reactivities (127), (40), (39), (13), (13), (13), (13), (1), (1)
Applications (97), (73), (23), (19), (10), (7), (6), (4), (4), (3), (3), (2), (2), (2), (2), (1), (1)
Conjugates (8), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (4), (4), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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