Bone Morphogenetic Protein 7 (BMP7) (AA 293-431) antibody

Details for Product No. ABIN121162
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AA 293-431
Human, Mouse (Murine), Rat (Rattus)
Clonality (Clone)
Monoclonal ()
Enzyme Immunoassay (EIA), Western Blotting (WB)
Pubmed 4 references available
Quantity 0.1 mL
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Catalog No. ABIN121162
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Immunogen Recombinant human BMP7 (293-431 aa) purified from E. coli
Clone 4-00E-007
Isotype IgG1
Specificity This antibody reacts with BMP-7.
Purification Protein-G affinity chromatography
Alternative Name BMP7
Background BMP-7 (bone morphogenetic protein-7), also known as OP-1 (osteogenic protein-1), is a member of the transforming growth factor β (TGFβ) superfamily. BMP-7 plays an essential role during ontogeny of the mammalian eye and kidney, also, is expressed in heart, lung, small intestine, limb bud and teeth. In addition, noggin, one of the soluble BMP antagonists, regulated the action of BMPs on mesenchymal precursor cells, partially through a feedback type of inhibition.Synonyms: BMP-7, Bone morphogenetic protein 7, OP1, Osteogenic protein 1
Gene ID 655
UniProt P18075
Research Area Organogenesis, Cell Cycle, Extracellular Matrix, Signaling, Hormones, Cytokines
Application Notes ELISA. Western blot (1/500 - 1/1,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, containing 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Bone Morphogenetic Protein 7 (BMP7) (AA 293-431) antibody Western blot analysis.,.The extracts of mouse kidney (MK) and rat heart (RH) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human BMP7 antibody (1:1,000). Protein was visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
General Gregory, Ono, Charbonneau et al.: "The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix." in: The Journal of biological chemistry, Vol. 280, Issue 30, pp. 27970-80, 2005 (PubMed).

Groppe, Greenwald, Wiater et al.: "Structural basis of BMP signalling inhibition by the cystine knot protein Noggin." in: Nature, Vol. 420, Issue 6916, pp. 636-42, 2002 (PubMed).

Godin, Takaesu, Robertson et al.: "Regulation of BMP7 expression during kidney development." in: Development (Cambridge, England), Vol. 125, Issue 17, pp. 3473-82, 1998 (PubMed).

Sampath, Coughlin, Whetstone et al.: "Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily." in: The Journal of biological chemistry, Vol. 265, Issue 22, pp. 13198-205, 1990 (PubMed).

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