Parkinson Protein 7 (PARK7) (AA 1-189), (N-Term) antibody

Details for Product No. ABIN121180
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Antigen
Synonyms dj1, zgc:103725, DJ-1, Dj1, DJ1, CAP1, SP22
Epitope
AA 1-189, N-Term
(27), (17), (7), (7), (6), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(156), (71), (56), (16), (15), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Host
Mouse
(130), (30), (9), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(152), (91), (42), (37), (20), (20), (10), (10), (9), (2)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN121180
412.50 $
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Immunogen Recombinant human GST-DJ1 (1-189 aa) purified from E. coli
Clone 1B11
Isotype IgG1
Purification Protein-G affinity chromatography
Alternative Name DJ-1 / PARK7
Background Park7/DJ-1, which is a small 189 amino acid protein, is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA- binding, androgen-receptor signaling and oxidative stress. Mutations in the Park7/DJ-1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (Park7). Alternate Names: PARK-7, Oncogene DJ1, Parkinson Disease Protein 7, Autosomal Recessive Early Onset.
UniProt Q99497
Application Notes The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Recommended dilution for Western blot is 1:500 ~ 1:2,000 (starting dilution is 1:1,000). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer Phosphate-Buffered Saline (pH 7.4) with 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Can be stored at 2-8°C for up to one month, but store at -20°C for long term storage. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Expiry Date 12 months
General Bonifati, Rizzu, van Baren et al.: "Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism." in: Science (New York, N.Y.), Vol. 299, Issue 5604, pp. 256-9, 2003 (PubMed).

Meulener, Graves, Sampathu et al.: "DJ-1 is present in a large molecular complex in human brain tissue and interacts with alpha-synuclein." in: Journal of neurochemistry, Vol. 93, Issue 6, pp. 1524-32, 2005 (PubMed).

Junn, Taniguchi, Jeong et al.: "Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 27, pp. 9691-6, 2005 (PubMed).

Zhou, Freed: "DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity." in: The Journal of biological chemistry, Vol. 280, Issue 52, pp. 43150-8, 2005 (PubMed).

Validation Images
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