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Details for Product No. ABIN129552

p28 ING5 (AA 127-140) antibody

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Antigen
Epitope
AA 127-140
Reactivity
Human
Host
Goat
Clonality Polyclonal
Application
Western Blotting (WB), ELISA
Pubmed 1 reference available
Catalog no. ABIN129552
Quantity 100 µg
Price
361.90 $   Plus shipping costs $45.00 and if applicable $26.40 dry ice
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This affinity purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 127-140 of Human p28 ING5protein (Inhibitor of growth family, member 5). This sequence shows homology to and 2 for ING5.
Isotype IgG
Characteristics Concentration Definition: by UV absorbance at 280 nm
Background P28 ING5 is a tumor suppressor protein similar to ING1 that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.  Multiple alternatively spliced transcript variants have been observed.  The accession number listed below is for variant (1) encodes the longest isoform.
Synonyms: ING5 antibody, Inhibitor of growth family member 5 antibody
Gene ID 84289, AAH05370 (isoform 2)
NCBI Accession 18644730
UniProt Q8WYH8
Application Notes This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 28 kDa or 26 kDa in size corresponding to variants of ING5 by western blotting in the appropriate cell lysate or extract.
Restrictions For Research Use only
Format Liquid
Concentration 1.52 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Storage -20 °C
Iizuka, Sarmento, Sekiya et al.: "Hbo1 Links p53-dependent stress signaling to DNA replication licensing." in: Molecular and cellular biology, Vol. 28, Issue 1, pp. 140-53, 2007 (PubMed).

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