CD72.1 antibody

Details for Product No. ABIN135264
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Antigen
Reactivity
Mouse (Murine)
(13)
Host
Mouse
(13)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (3), (1)
Application
Flow Cytometry (FACS)
(13)
Pubmed 2 references available
Quantity 0.5 mg
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Catalog No. ABIN135264
313.50 $
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Immunogen DBA/2 mouse spleen cells 1
Clone 10-1-D2
Isotype IgG2b
Characteristics The antibody detects: Mouse CD72.1/Lyb-2.1, 45 kDa Murine
However, 10-1.D.2 can itself trigger a positive signal by binding CD72.
Purification Purified
Background CD72.1/Lyb-2.1, a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells, and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 (Ly-1) which is distributed on all T cells and a small number of B cells. The 10-1.D.2 monoclonal antibody blocks binding of CD5 to CD72 on the B cell surface, which leads to inhibition of the positive signal resulting from CD5/CD72 pairing.
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Comment

In vitro blocking and proliferation assays

Sample Volume 1 mL
Restrictions For Research Use only
Buffer Product is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of 100 mM borate buffered saline, pH 8.0.
Preservative Azide free
Handling Advice Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage 4 °C
General Beavil, Edmeades, Gould et al.: "Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (Fc epsilon RII/CD23) and related C-type lectins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 2, pp. 753-7, 1992 (PubMed).

Luo, Van de Velde, von Hoegen et al.: "Ly-1 (CD5), a membrane glycoprotein of mouse T lymphocytes and a subset of B cells, is a natural ligand of the B cell surface protein Lyb-2 (CD72)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 6, pp. 1630-4, 1992 (PubMed).

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