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Ankyrin Repeat-Containing Protein (EHMT2) (AA 621-1000), (C-Term) antibody

Details for Product No. ABIN1449182, Supplier: Login to see
Antigen
  • T27C4.12
  • T27C4_12
  • DL3235W
  • FCAALL.188
  • ACCELERATED CELL DEATH 6
  • DL3240W
  • FCAALL.190
  • T18B16.120
  • T18B16_120
  • F9H3.13
  • F9H3_13
  • F9H3.7
  • F9H3_7
  • F9H3.9
  • F9H3_9
  • F9H3.6
  • F9H3_6
  • F13G24.40
  • T20K14.110
  • T20K14_110
  • MWD22.10
  • MWD22_10
  • MRB17.12
  • MRB17_12
  • MGO3.5
  • MGO3_5
  • MAF19.22
  • MAF19_22
  • Bat8
  • G9a
  • Ng36
  • D17Ertd710e
  • KMT1C
  • NG36
  • BAT8
  • C6orf30
  • G9A
  • GAT8
Epitope
C-Term, AA 621-1000
18
15
7
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
55
20
13
2
2
Host
Hamster
59
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
1
Application
Western Blotting (WB)
54
22
15
8
6
5
2
1
1
1
Supplier
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Immunogen GST-mouse G9a C-terminal protein (a.a. 621-1000)
Clone 01-01-14
Isotype IgG
Specificity This antibody reacts with both the 165 kDa G9a-L isoform and the 140 kDa G9a-S isoform.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse
Purification Protein A agarose
Alternative Name BAT8 (EHMT2 Antibody Abstract)
Background G9a (BAT8, NG36) is a major histone methyltransferase that acts by adding a methyl group to the Lys9 amino acid on histone H3 proteins. Methylation of Lys9 on histone H3 is important for the regulation of the expression of crucial genes during embryogenesis. Methylation of Lys9 may also play a role in tumorigenesis, since deregulation of histone H3 Lys9 methylation in G9a-deficient cells induces the expression of Mage-2a, a tumor-specific protein whose function is unknown. The 165 kDa G9a protein has an unusual structure, containing 24 contiguous glutamate residues in the N-terminus and 6 contiguous copies of a 33-amino acid ankyrin repeat in the C-terminus. The presence of the ankyrin repeats suggest that G9a may be involved in intracellular protein-protein interactions. G9a is expressed in monocytic, macrophage, hepatocyte, T-cell, B-cell, epithelial, and promyelocytic cell lines.Synonyms: C6orf30, EHMT2, Euchromatic histone-lysine N-methyltransferase 2, H3 lysine-9 specific 3, H3-K9-HMTase 3, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3, Histone-lysine N-methyltransferase, KMT1C, Lysine N-methyltransferase 1C, NG36, Protein G9A
Gene ID 110147
NCBI Accession NP_665829
UniProt Q9Z148
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-Ankyrin Repeat-Containing Protein (EHMT2) (AA 621-1000), (C-Term) antibody (ABIN1449182) anti-Ankyrin Repeat-Containing Protein (EHMT2) (AA 621-1000), (C-Term) antibody
Background publications Tachibana, Sugimoto, Nozaki et al.: "G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis." in: Genes & development, Vol. 16, Issue 14, pp. 1779-91, 2002 (PubMed).

Tachibana, Sugimoto, Fukushima et al.: "Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3." in: The Journal of biological chemistry, Vol. 276, Issue 27, pp. 25309-17, 2001 (PubMed).