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Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (AA 24-440), (Extracellular Domain) antibody

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  • AU042498
  • glial cell line derived neurotrophic factor family receptor alpha 1
  • GDNF family receptor alpha 1
  • Gfra1
Extracellular Domain, AA 24-440
Clonality (Clone)
Monoclonal ()
Western Blotting (WB)
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Immunogen Tecombinant human GFRalpha1 extracellular domain (24-440 aa)
Clone 4G10
Isotype IgG2b
Specificity This antibody detects GFRα1 (60 kDa). Reacts with HCC-1500, MCF-7, but NOT with BT-20, ZR-75-1.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Protein A agarose
Alternative Name GFRA1 / GDNFR-alpha (GFRA1 Antibody Abstract)
Background Glial cell line-derived neurotrophic factor (GDNF) family plays a critical role in neurodevelopment and survival of central and peripheral neurons. The biological activity of GDNF family through receptor protein tyrosine kinase Ret and require a ligand specific co-receptor a (GFRa1, binds GDNF, whereas GFRa2 binds NRTN, GFRa3 binds ARTN and GFRa4 binds PSPN). Human GFRa1 is constituted from 465 amino acids and attach to the cell membrane by glycosylphosphatidylinositol (GPI) anchoring manner. It is widely accepted that homodimeric GDNF induce the complex formation of GFRa1 and further the stoichiometry of the signaling complex with GDNF2-GFRa12-Ret2, but the mechanism of complex formation remain unclear.Synonyms: GDNF family receptor alpha-1, GDNF receptor alpha, GDNFRA, GFR-alpha-1, RET ligand 1, RETL1, TGF-beta-related neurotrophic factor receptor 1, TRNR1
Gene ID 2674
NCBI Accession NP_001138925
UniProt P56159
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliqouts) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (AA 24-440), (Extracellular Domain) antibody (ABIN1449285) anti-Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (AA 24-440), (Extracellular Domain) antibody
Background publications Müller, Tora: "The multicoloured world of promoter recognition complexes." in: The EMBO journal, Vol. 23, Issue 1, pp. 2-8, 2004 (PubMed).

Wang, Zhang, Zhang, Zhu, He, Lu, Ding, Chen: "Identification of the key amino acids of glial cell line-derived neurotrophic factor family receptor alpha1 involved in its biological function." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 109-16, 2003 (PubMed).

Udvardy: "Dividing the empire: boundary chromatin elements delimit the territory of enhancers." in: The EMBO journal, Vol. 18, Issue 1, pp. 1-8, 1999 (PubMed).

Sanicola, Hession, Worley, Carmillo, Ehrenfels, Walus, Robinson, Jaworski, Wei, Tizard, Whitty, Pepinsky, Cate: "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 12, pp. 6238-43, 1997 (PubMed).

Jing, Wen, Yu, Holst, Luo, Fang, Tamir, Antonio, Hu, Cupples, Louis, Hu, Altrock, Fox: "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF." in: Cell, Vol. 85, Issue 7, pp. 1113-24, 1996 (PubMed).