Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (Extracellular Domain), (AA 24-440) antibody

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Synonyms AU042498
Extracellular Domain, AA 24-440
(5), (1), (1), (1), (1), (1), (1)
(17), (4), (4)
(10), (7)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB)
(12), (8), (3), (1), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN1449285
Quantity 0.1 mg
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Immunogen Tecombinant human GFRalpha1 extracellular domain (24-440 aa)
Clone 4G10
Isotype IgG2b
Specificity This antibody detects GFRalpha1 (60 kDa). Reacts with HCC-1500, MCF-7, but NOT with BT-20, ZR-75-1.
Purification Protein A agarose
Alternative Name GFRA1 / GDNFR-alpha
Background Glial cell line-derived neurotrophic factor (GDNF) family plays a critical role in neurodevelopment and survival of central and peripheral neurons. The biological activity of GDNF family through receptor protein tyrosine kinase Ret and require a ligand specific co- receptor a (GFRa1, binds GDNF, whereas GFRa2 binds NRTN, GFRa3 binds ARTN and GFRa4 binds PSPN). Human GFRa1 is constituted from 465 amino acids and attach to the cell membrane by glycosylphosphatidylinositol (GPI) anchoring manner. It is widely accepted that homodimeric GDNF induce the complex formation of GFRa1 and further the stoichiometry of the signaling complex with GDNF2-GFRa12-Ret2, but the mechanism of complex formation remain unclear.
Alternate names: GDNF family receptor alpha-1, GDNF receptor alpha, GDNFRA, GFR-alpha-1, RET ligand 1, RETL1, TGF-beta-related neurotrophic factor receptor 1, TRNR1
Gene ID 2674
NCBI Accession NP_001138925.1
UniProt P56159
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Upon receipt, store (in aliqouts) at -20 °C.
Expiry Date 12 months
Supplier Images
anti-Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (Extracellular Domain), (AA 24-440) antibody anti-Glial Cell Line Derived Neurotrophic Factor Family Receptor alpha 1 (GFRA1) (Extracellular Domain), (AA 24-440) antibody
Background publications Jing, Wen, Yu et al.: "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF." in: Cell, Vol. 85, Issue 7, pp. 1113-24, 1996 (PubMed).

Sanicola, Hession, Worley et al.: "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 12, pp. 6238-43, 1997 (PubMed).

Udvardy: "Dividing the empire: boundary chromatin elements delimit the territory of enhancers." in: The EMBO journal, Vol. 18, Issue 1, pp. 1-8, 1999 (PubMed).

Wang, Zhang, Zhang et al.: "Identification of the key amino acids of glial cell line-derived neurotrophic factor family receptor alpha1 involved in its biological function." in: The Journal of biological chemistry, Vol. 279, Issue 1, pp. 109-16, 2003 (PubMed).

Müller, Tora: "The multicoloured world of promoter recognition complexes." in: The EMBO journal, Vol. 23, Issue 1, pp. 2-8, 2004 (PubMed).

Hosts (10), (7)
Reactivities (17), (4), (4)
Applications (12), (8), (3), (1), (1), (1), (1)
Epitopes (5), (1), (1), (1), (1), (1), (1)
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