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Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) antibody

Details for Product No. ABIN1449593
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Antigen
Synonyms
MGC69006, MGC89867, MAP1LC3A, map1lc3a, Anx3, LC3, LRRGT00047, ATG8E, LC3A, MAP1ALC3, MAP1BLC3, 1010001H21Rik, 4922501H04Rik, LC3a, zgc:77094, Map1lc3, zgc:56434, wu:fb60g11, Lc3, b3gnt5, fb12f12, wu: ... show more
MGC69006, MGC89867, MAP1LC3A, map1lc3a, Anx3, LC3, LRRGT00047, ATG8E, LC3A, MAP1ALC3, MAP1BLC3, 1010001H21Rik, 4922501H04Rik, LC3a, zgc:77094, Map1lc3, zgc:56434, wu:fb60g11, Lc3, b3gnt5, fb12f12, wu:fb12f12, wu:fe50g08 show less
Reactivity
Human
(174), (84), (74), (42), (25), (25), (15), (12), (3), (3), (1), (1), (1)
Host
Rabbit
(152), (19), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (10), (10), (10), (7), (7), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(138), (68), (59), (39), (30), (30), (20), (16), (15), (10), (2), (2), (1)
Pubmed 9 references available
Quantity 0.4 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1449593
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Immunogen Full-length recombinant Human LC3
Specificity This antibody recognizes Human LC3 (APG8). Other species not tested.
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name LC3
Background Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane- bound form, LC3-II
Alternate names: Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, LC3A, MAP1 light chain 3-like protein 1, MAP1A / 1B light chain 3 A, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1LC3A, Microtubule-associated protein 1 light chain 3 alpha, Microtubule-associated proteins 1A/1B light chain 3A
Gene ID 84557
NCBI Accession NM_032514.2
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Mann, Hammarback: "Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B." in: Journal of neuroscience research, Vol. 43, Issue 5, pp. 535-44, 1997 (PubMed).

He, Dang, Dai et al.: "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B." in: The Journal of biological chemistry, Vol. 278, Issue 31, pp. 29278-87, 2003 (PubMed).

HIRASHIMA, TAKAKU: "Experimental studies on erythropoietin. II. The relationship between juxtaglomerular cells and erythropoietin." in: Blood, Vol. 20, pp. 1-8 (PubMed).

Tanida, Sou, Ezaki et al.: "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates." in: The Journal of biological chemistry, Vol. 279, Issue 35, pp. 36268-76, 2004 (PubMed).

Zheng, Liu, Li et al.: "RNA interference-mediated downregulation of Beclin1 attenuates cerebral ischemic injury in rats." in: Acta pharmacologica Sinica, Vol. 30, Issue 7, pp. 919-27, 2009 (PubMed).

Mizuno, Yasuo, Bogaard et al.: "Inhibition of histone deacetylase causes emphysema." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 300, Issue 3, pp. L402-13, 2011 (PubMed).

Wojtkowiak, Sane, Kleinman et al.: "Aborted autophagy and nonapoptotic death induced by farnesyl transferase inhibitor and lovastatin." in: The Journal of pharmacology and experimental therapeutics, Vol. 337, Issue 1, pp. 65-74, 2011 (PubMed).

Liu, Jia, Zhang et al.: "Involvement of melatonin in autophagy-mediated mouse hepatoma H22 cell survival." in: International immunopharmacology, Vol. 12, Issue 2, pp. 394-401, 2012 (PubMed).

Zhang, Morgan, Chen et al.: "Induction of autophagy is essential for monocyte-macrophage differentiation." in: Blood, Vol. 119, Issue 12, pp. 2895-905, 2012 (PubMed).

Validation Images
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