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Microtubule-Associated Protein 1 Light Chain 3 alpha (MAP1LC3A) (N-Term), (AA 1-30) antibody

Details for Product No. ABIN1449594
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Antigen
Synonyms
MGC69006, MGC89867, MAP1LC3A, map1lc3a, Anx3, LC3, LRRGT00047, ATG8E, LC3A, MAP1ALC3, MAP1BLC3, 1010001H21Rik, 4922501H04Rik, LC3a, zgc:77094, Map1lc3, zgc:56434, wu:fb60g11, Lc3, b3gnt5, fb12f12, wu: ... show more
MGC69006, MGC89867, MAP1LC3A, map1lc3a, Anx3, LC3, LRRGT00047, ATG8E, LC3A, MAP1ALC3, MAP1BLC3, 1010001H21Rik, 4922501H04Rik, LC3a, zgc:77094, Map1lc3, zgc:56434, wu:fb60g11, Lc3, b3gnt5, fb12f12, wu:fb12f12, wu:fe50g08 show less
Epitope
N-Term, AA 1-30
(23), (22), (13), (11), (10), (10), (9), (7), (6), (6), (6), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(174), (83), (73), (42), (25), (25), (15), (12), (3), (3), (1), (1), (1)
Host
Rabbit
(152), (19), (4), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (10), (10), (10), (7), (7), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(138), (68), (59), (38), (30), (29), (19), (16), (15), (10), (2), (2), (1)
Pubmed 15 references available
Quantity 0.4 mL
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Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1449594
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Immunogen KLH conjugated synthetic peptide between 1~30 amino acids from the N-term of Human LC3
Specificity This antibody recognizes LC3 (APG8A) (N-term).
Purification Saturated Ammonium Sulfate precipitation followed by dialysis against PBS
Alternative Name LC3
Background Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane- bound form, LC3-II
Alternate names: Autophagy-related protein LC3 A, Autophagy-related ubiquitin-like modifier LC3 A, LC3A, MAP1 light chain 3-like protein 1, MAP1A / 1B light chain 3 A, MAP1A/1B light chain 3 A, MAP1A/MAP1B LC3 A, MAP1LC3A, Microtubule-associated protein 1 light chain 3 alpha, Microtubule-associated proteins 1A/1B light chain 3A
Gene ID 84557
NCBI Accession NM_032514.2
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Johnson, Silsbee: "Thermodynamic analysis of interfacial transport and of the thermomagnetoelectric system." in: Physical review. B, Condensed matter, Vol. 35, Issue 10, pp. 4959-4972, 1999 (PubMed).

Hung, Huang, Liou et al.: "Autophagy protects neuron from Abeta-induced cytotoxicity." in: Autophagy, Vol. 5, Issue 4, pp. 502-10, 2009 (PubMed).

English, Chemali, Duron et al.: "Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection." in: Nature immunology, Vol. 10, Issue 5, pp. 480-7, 2009 (PubMed).

Chen, Azad, Gibson: "Superoxide is the major reactive oxygen species regulating autophagy." in: Cell death and differentiation, Vol. 16, Issue 7, pp. 1040-52, 2009 (PubMed).

Bohensky, Leshinsky, Srinivas et al.: "Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression." in: Pediatric nephrology (Berlin, Germany), Vol. 25, Issue 4, pp. 633-42, 2010 (PubMed).

Ma, Huang, Chen et al.: "Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease." in: Neuropathology and applied neurobiology, Vol. 36, Issue 4, pp. 312-9, 2010 (PubMed).

Li, Ma, Wang et al.: "c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3." in: Cell death and differentiation, Vol. 17, Issue 8, pp. 1277-87, 2010 (PubMed).

Cirstea, Hideshima, Rodig et al.: "Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma." in: Molecular cancer therapeutics, Vol. 9, Issue 4, pp. 963-75, 2010 (PubMed).

Geng, Kohli, Klocke et al.: "Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent." in: Neuro-oncology, Vol. 12, Issue 5, pp. 473-81, 2010 (PubMed).

Wang, Hossain, Tan et al.: "Inhibition of isoprenylcysteine carboxylmethyltransferase induces autophagic-dependent apoptosis and impairs tumor growth." in: Oncogene, Vol. 29, Issue 35, pp. 4959-70, 2010 (PubMed).

Hino, Hamada, Tajika et al.: "Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells." in: Journal of electron microscopy, Vol. 59, Issue 6, pp. 495-501, 2010 (PubMed).

Li, Castano, Hudson et al.: "The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 12, pp. 4767-81, 2010 (PubMed).

Bains, Zaegel, Mize-Berge et al.: "IGF-I stimulates Rab7-RILP interaction during neuronal autophagy." in: Neuroscience letters, Vol. 488, Issue 2, pp. 112-7, 2011 (PubMed).

Lee, Liao, Tsai et al.: "Identification and anti-human glioblastoma activity of tagitinin C from Tithonia diversifolia methanolic extract." in: Journal of agricultural and food chemistry, Vol. 59, Issue 6, pp. 2347-55, 2011 (PubMed).

Nascimento-Ferreira, Santos-Ferreira, Sousa-Ferreira et al.: "Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease." in: Brain : a journal of neurology, Vol. 134, Issue Pt 5, pp. 1400-15, 2011 (PubMed).

Validation Images
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