Unc-51 Like Kinase 1 (C. Elegans) (ULK1) (AA 649-679) antibody

Details for Product No. ABIN1449620
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms Unc51.1, AU041434, mKIAA0722, ATG1, ATG1A, UNC51, hATG1, ULK1, si:dkey-11o18.7, ulk1
Epitope
AA 649-679
(18), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(61), (32), (28), (24), (12), (12), (2), (1)
Host
Rabbit
(58), (4), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(30), (20), (13), (13), (12), (7), (4), (3), (1)
Pubmed 3 references available
Catalog no. ABIN1449620
Quantity 0.4 mL
Price
357.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen KLH conjugated synthetic peptide between 649~679 amino acids from the center region of Human APG1 Genename: ULK1
Specificity This antibody recognizes Human APG1 / ULK1 (649-679). Other species not tested.
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name Unc-51-like kinase 1 (ULK1)
Background Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Two human homologs of the yeast autophagy-specific kinase exist: ULK1(APG1) and ULK2. APG1 plays a critical role in regulating key elements of the autophagy pathway. APG1 stimulates autophagy, leading to autophagy-dependent restriction of cell growth and ultimately cell apoptosis at high levels of activity, and is a negative regulator of mTOR signaling.
Alternate names: KIAA0722, Serine/threonine-protein kinase ULK1
Gene ID 8408
NCBI Accession NP_003556.1
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Kuroyanagi, Yan, Seki et al.: "Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment." in: Genomics, Vol. 51, Issue 1, pp. 76-85, 1998 (PubMed).

Yeo, Kim, Park et al.: "Retraction: Blockage of intracellular proton extrusion with proton pump inhibitor induces apoptosis in gastric cancer." in: Cancer science, Vol. 99, Issue 1, pp. 185, 2007 (PubMed).

Jiang, Li, Zhu et al.: "Intensive expression of UNC-51-like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma." in: Cancer science, Vol. 102, Issue 8, pp. 1568-75, 2011 (PubMed).

Hosts (58), (4), (1)
Reactivities (61), (32), (28), (24), (12), (12), (2), (1)
Applications (30), (20), (13), (13), (12), (7), (4), (3), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (18), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
back to top