Autophagy Related 2B (ATG2B) (N-Term) antibody

Details for Product No. ABIN1449993
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Antigen
Synonyms C14orf103, 2410024A21Rik, AI047755, AI503411, AW558123, C030004M05Rik, C630028L02Rik, mKIAA4067
Epitope
N-Term
(14), (7), (2)
Reactivity
Human
(16), (2)
Host
Rabbit
(15), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(16), (11), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1449993
401.50 $
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Immunogen A 19 amino acid synthetic peptide near the amino terminus of Human ATG2B
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name ATG2B
Background Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.Synonyms: Autophagy related 2 homolog B
Molecular Weight 229 kDa
Gene ID 55102
NCBI Accession NP_060506
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Kisen, Tessitore, Costelli et al.: "Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells." in: Carcinogenesis, Vol. 14, Issue 12, pp. 2501-5, 1994 (PubMed).

Kamada, Funakoshi, Shintani et al.: "Tor-mediated induction of autophagy via an Apg1 protein kinase complex." in: The Journal of cell biology, Vol. 150, Issue 6, pp. 1507-13, 2000 (PubMed).

Gozuacik, Kimchi: "Autophagy as a cell death and tumor suppressor mechanism." in: Oncogene, Vol. 23, Issue 16, pp. 2891-906, 2004 (PubMed).

Kang, Kim, Oh et al.: "Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability." in: The Journal of pathology, Vol. 217, Issue 5, pp. 702-6, 2009 (PubMed).

Velikkakath, Nishimura, Oita et al.: "Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets." in: Molecular biology of the cell, Vol. 23, Issue 5, pp. 896-909, 2012 (PubMed).

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