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ATG2B antibody (N-Term)

ATG2B Reactivity: Human WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1449993
  • Target See all ATG2B products
    ATG2B (Autophagy Related 2B (ATG2B))
    Binding Specificity
    • 14
    • 10
    • 5
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 26
    • 10
    • 2
    Human
    Host
    • 26
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 12
    • 4
    • 3
    • 3
    • 2
    • 2
    This ATG2B antibody is un-conjugated
    Application
    • 20
    • 16
    • 2
    • 2
    • 2
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    A 19 amino acid synthetic peptide near the amino terminus of Human ATG2B
    Isotype
    IgG
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    ATG2B (Autophagy Related 2B (ATG2B))
    Alternative Name
    ATG2B (ATG2B Products)
    Synonyms
    C14orf103 antibody, 2410024A21Rik antibody, AI047755 antibody, AI503411 antibody, AW558123 antibody, C030004M05Rik antibody, C630028L02Rik antibody, mKIAA4067 antibody, autophagy related 2B antibody, ATG2B antibody, Atg2b antibody
    Background
    Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.Synonyms: Autophagy related 2 homolog B
    Molecular Weight
    229 kDa
    Gene ID
    55102
    NCBI Accession
    NP_060506
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