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TCTEX1D4 antibody (Tctex1 Domain Containing 4) (N-Term)

Details for Product anti-TCTEX1D4 Antibody No. ABIN1450005, Supplier: Log in to see
  • 4833401D15Rik
  • N22.1
  • Tctex-2-beta
Human, Mouse (Murine), Rat (Rattus)
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
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Immunogen 19 amino acid synthetic peptide near the amino terminus of Human TCTEX1D4
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name TCTEX1D4
Background Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. TCTEX1 is a cytoplasmic dynein light chain found in a complex with Na+ CP type X (SCN10A). TCTEX1D4, also called TCTEX2 beta, interacts with different members of the TGF-beta receptor family, and when overexpressed, inhibits TGF-beta signaling.Synonyms: RP11-269F19.9, Tctex-2-beta, Tctex1 domain-containing protein 4
Molecular Weight 24 kDa
Gene ID 343521
NCBI Accession NP_001013654
Research Area Stem Cells
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-TCTEX1D4 antibody (Tctex1 Domain Containing 4) (N-Term) (ABIN1450005) Western blot analysis of TCTEX1D4 in mouse liver tissue lysate with TCTEX1D4 antibody...
Background publications Meng, Lux, Holloschi, Li, Hughes, Foerg, McCarthy, Heagerty, Kioschis, Hafner, Garland: "Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors." in: The Journal of biological chemistry, Vol. 281, Issue 48, pp. 37069-80, 2006 (PubMed).

Li, Lee, Cooper: "NudEL targets dynein to microtubule ends through LIS1." in: Nature cell biology, Vol. 7, Issue 7, pp. 686-90, 2005 (PubMed).

Chuang, Yeh, Bollati, Conde, Canavosio, Caceres, Sung: "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth." in: Developmental cell, Vol. 9, Issue 1, pp. 75-86, 2005 (PubMed).

He, Francis, Myers, Yu, Black, Baas: "Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments." in: The Journal of cell biology, Vol. 168, Issue 5, pp. 697-703, 2005 (PubMed).

Watanabe, Fujiwara, Shimizu, Okuno, Suzuki, Takahashi, Nakamura, Hirai: "Cloning, expression, and mapping of TCTEL1, a putative human homologue of murine Tcte1, to 6q." in: Cytogenetics and cell genetics, Vol. 73, Issue 1-2, pp. 153-6, 1996 (PubMed).