Transglutaminase 7 (TGM7) (Middle Region) antibody

Details for Product No. ABIN1450066
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Antigen
Synonyms TGM7, TGMZ, TGz
Epitope
Middle Region
(3), (2), (1), (1)
Reactivity
Human, Mouse (Murine)
(20), (8), (1), (1)
Host
Rabbit
(14), (3), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(21), (15), (5), (5), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN1450066
401.50 $
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Immunogen 13 amino acid synthetic peptide near the center of Human TGM7
Isotype IgG
Specificity At least two isoforms of TGM7 are known to exist. This antibody will recognize both isoforms and is predicted to not cross-react with other TGase protein family members.
Purification Affinity chromatography purified via peptide column
Alternative Name Transglutaminase-7 (TGM7)
Background Transglutaminases (TGM) are a family of structurally and functionally related Ca2+-dependent enzymes (TGases) that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. TGases influence numerous biological processes, including blood coagulation, cell differentiation, fertilization and apoptosis. TGM7 belongs to the transglutaminase superfamily and is also thought to catalyze the cross-linking of proteins, often resulting in stabilization of protein assemblies. Little is known of the role of TGM7, but defects in the highly related protein TGM5 are associated with acral peeling skin syndrome.
Alternate names: Protein-glutamine gamma-glutamyltransferase Z, TGZ, TGase Z
Gene ID 116179
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Ueki, Takagi, Saito: "Dual functions of transglutaminase in novel cell adhesion." in: Journal of cell science, Vol. 109 ( Pt 11), pp. 2727-35, 1997 (PubMed).

Grenard, Bates, Aeschlimann: "Evolution of transglutaminase genes: identification of a transglutaminase gene cluster on human chromosome 15q15. Structure of the gene encoding transglutaminase X and a novel gene family member, transglutaminase Z." in: The Journal of biological chemistry, Vol. 276, Issue 35, pp. 33066-78, 2001 (PubMed).

Cassidy, van Steensel, Steijlen et al.: "A homozygous missense mutation in TGM5 abolishes epidermal transglutaminase 5 activity and causes acral peeling skin syndrome." in: American journal of human genetics, Vol. 77, Issue 6, pp. 909-17, 2005 (PubMed).

Dewaele, Rasschaert, Wildemauwe et al.: "Polyphasic characterization of Salmonella Enteritidis isolates on persistently contaminated layer farms during the implementation of a national control program with obligatory vaccination: a longitudinal study." in: Poultry science, Vol. 91, Issue 11, pp. 2727-35, 2012 (PubMed).

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