TNFRSF12A antibody (PE)

Catalog No. ABIN1819127

Product Details anti-TNFRSF12A Antibody (PE)

Target: TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF12A antibody is conjugated to PE

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Recognizes human CD266, otherwise known as Fn14/TWEAK Receptor, a 14kD type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed by a variety of tissues, including the heart, lung and kidney, and at elevated levels by human brain and liver tumors. The interaction between CD266 and its ligand CD255 (TWEAK), induces the proliferation and migration of endothelial cells and also angiogenesis, and studies have shown that CD255-induced apoptosis of some tumor cell lines is mediated by CD266, see for details. Clone ITEM-4 is cross-reactive with mouse CD266, and also with Rat-1 cells in flow cytometry.

Purification: Protein G purified

Immunogen: Human CD266 transfected P815 cells.

Type of Immunogen: Cells

Clone: ITEM-4

Isotype: IgG2b

Application Details

Application Notes: Approved: Flo, IHC, IHC-Fr, WB

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Distilled water

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide, 1 % BSA, 5 % sucrose

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze. Protect from light.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze. Protect from light.

Target Details for TNFRSF12A

Target: TNFRSF12A (Tumor Necrosis Factor Receptor Superfamily, Member 12A (TNFRSF12A))

Alternative Name: TNFRSF12A / FN14 (TNFRSF12A Products)

Background: Name/Gene ID: TNFRSF12A

Synonyms: TNFRSF12A, CD266 antigen, CD266, FGF-inducible 14, FN14, Tweak-receptor, TWEAKR

Gene ID: 51330

Pathways: Apoptosis, Regulation of Cell Size