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Details for Product No. ABIN182600

WW Domain Containing Transcription Regulator 1 (WWTR1) (N-Term) antibody

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Antigen
Synonyms TAZ, Taz, C78399, 2310058J06Rik, 2610021I22Rik, WWTR1
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN182600
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-WWTR1 antibody: synthetic peptide directed towards the N terminal of human WWTR1
Sequence PRLAGGAQHVRSHSSPASLQLGTGAGAAGSPAQQHAHLRQ QSYDVTDELP
Predicted Reactivity Bovine : 100%, Dog : 100%, Guinea pig : 100%, Human : 100%, Mouse : 100%, Pig : 100%, Rabbit : 100%, Rat : 100%
Characteristics This is a rabbit polyclonal antibody against WWTR1. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name WWTR1
Background TAZ (transctiptional coactivator with PDZ-binding motif), also known as WW domain containing transcription regulator 1 (WWTR1), is a member of the bicoid sub-family of homeodomain-containing transcription factors. TAZ is a 14-3-3 binding protein that co-activates Runx2-dependent gene transcription while repressing PPAR-gamma-dependent gene transcription. TAZ has been reported to be a modulator of mesenchymal stem cell differentiation. TAZ may also play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.
Molecular Weight 44kDa
Gene ID 25937
NCBI Accession NP_056287, NM_015472
UniProt Q9GZV5
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-WWTR1 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Hong, Hwang, McManus et al.: "TAZ, a transcriptional modulator of mesenchymal stem cell differentiation." in: Science (New York, N.Y.), Vol. 309, Issue 5737, pp. 1074-8, 2005 (PubMed).

Alternatives for antigen "WW Domain Containing Transcription Regulator 1 (WWTR1)", type "Antibodies"
Hosts (13), (7)
Reactivities (19), (1), (1), (1)
Applications (20), (5), (3), (3), (3), (3), (1)
Conjugates (1), (1)
Epitopes (4), (2), (2), (1), (1), (1)
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