WW Domain Containing Transcription Regulator 1 (WWTR1) (N-Term) antibody

Details for Product No. ABIN182600
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Antigen
Synonyms WWTR1, TAZ, 2310058J06Rik, 2610021I22Rik, C78399, Taz
Epitope
N-Term
(6), (5), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Human
(18), (1), (1), (1)
Host
Rabbit
(12), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1)
Application
Western Blotting (WB)
(19), (7), (3), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN182600
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human WWTR1
Sequence PRLAGGAQHV RSHSSPASLQ LGTGAGAAGS PAQQHAHLRQ QSYDVTDELP
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %
Characteristics This is a rabbit polyclonal antibody against WWTR1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name WWTR1
Background TAZ (transctiptional coactivator with PDZ-binding motif), also known as WW domain containing transcription regulator 1 (WWTR1), is a member of the bicoid sub-family of homeodomain-containing transcription factors. TAZ is a 14-3-3 binding protein that co-activates Runx2-dependent gene transcription while repressing PPAR-gamma-dependent gene transcription. TAZ has been reported to be a modulator of mesenchymal stem cell differentiation. TAZ may also play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.
Molecular Weight 44 kDa
Gene ID 25937
NCBI Accession NM_015472, NP_056287
UniProt Q9GZV5
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 400 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-WW Domain Containing Transcription Regulator 1 (WWTR1) (N-Term) antibody WB Suggested Anti-WWTR1 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysate
Background publications Hong, Hwang, McManus et al.: "TAZ, a transcriptional modulator of mesenchymal stem cell differentiation." in: Science (New York, N.Y.), Vol. 309, Issue 5737, pp. 1074-8, 2005 (PubMed).

Validation Images
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