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Details for Product No. ABIN182605

Zinc Finger Protein 163 (ZNF163) (N-Term) antibody

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Antigen
Synonyms Pal1, Gfi-1, Pal-1, AW495828, GFI-1, GFI1A, SCN2, ZNF163
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Rat (Rattus), Mouse (Murine), Dog (Canine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN182605
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-GFI1 antibody: synthetic peptide directed towards the N terminal of human GFI1
Sequence VPAPSRADSTSNAGGAKAEPRDRLSPESQLTEAPDRASAS PDSCEGSVCE
Predicted Reactivity Bovine : 100%, Human : 100%, Pig : 100%, Rat : 100%, Dog : 92%, Guinea pig : 92%, Horse : 92%, Mouse : 92%, Rabbit : 78%
Characteristics This is a rabbit polyclonal antibody against GFI1. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name GFI1
Background GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
Molecular Weight 45kDa
Gene ID 2672
NCBI Accession NP_005254, NM_005263
UniProt Q99684
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-GFI1 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Doan, Porter, Duan et al.: "Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells." in: Nucleic acids research, Vol. 32, Issue 8, pp. 2508-19, 2004 (PubMed).

Alternatives for antigen "Zinc Finger Protein 163 (ZNF163)", type "Antibodies"
Hosts (23), (11)
Reactivities (32), (16), (16), (13), (12), (2), (2), (1), (1)
Applications (23), (17), (10), (7), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (1)
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