Zinc Finger Protein 163 (ZNF163) (N-Term) antibody

Details for Product No. ABIN182605
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Antigen
Synonyms AW495828, Gfi-1, Pal-1, Pal1, GFI-1, GFI1A, SCN2, ZNF163
Epitope
N-Term
(7), (3), (2), (2), (2), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Dog (Canine), Human
(43), (17), (17), (13), (12), (4), (1), (1)
Host
Rabbit
(27), (20)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(36), (23), (10), (6), (6), (6), (3), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN182605
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human GFI1
Sequence VPAPSRADST SNAGGAKAEP RDRLSPESQL TEAPDRASAS PDSCEGSVCE
Predicted Reactivity Bovine : 100 %, Human : 100 %, Pig : 100 %, Rat : 100 %, Dog : 90 %, Guinea pig : 90 %, Horse : 90 %, Mouse : 90 %, Rabbit : 70 %
Characteristics This is a rabbit polyclonal antibody against GFI1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name GFI1
Background GFI1 may be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. GFI1 may be involved in tumor progression. Defects in GFI1 are a cause of autosomal dominant severe congenital neutropenia (SCN) and dominant nonimmune chronic idiopathic neutropenia of adults (NI-CINA) This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.
Molecular Weight 45 kDa
Gene ID 2672
NCBI Accession NP_005254, NM_005263
UniProt Q99684
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 422 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Background publications Doan, Porter, Duan et al.: "Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells." in: Nucleic acids research, Vol. 32, Issue 8, pp. 2508-19, 2004 (PubMed).

Validation Images
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