Zinc Finger E-Box Binding Homeobox 2 (ZEB2) (N-Term) antibody

Details for Product No. ABIN182863
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Antigen
Synonyms ZFHX1B, zfhx1b, XSip1, sip1, HSPC082, SIP-1, SIP1, SMADIP1, ZEB2, 9130203F04Rik, D130016B08Rik, Zfhx1b, Zfx1b, Zfxh1b, mKIAA0569, si:dkey-52o2.2, sip1a, wu:fc92g08, sip1b
Epitope
N-Term
(19), (10), (7), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Xenopus laevis, Cow (Bovine), Zebrafish (Danio rerio), Human
(58), (28), (27), (2), (2), (2), (1)
Host
Rabbit
(47), (7), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(56), (41), (17), (14), (11), (10), (8), (2), (1)
Pubmed 2 references available
Quantity 50 μg
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Catalog No. ABIN182863
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Immunogen Synthetic peptide directed towards the N terminal of human ZFHX1B
Sequence NVVDTGSETD EEDKLHIAED DGIANPLDQE TSPASVPNHE SSPHVSQALL
Predicted Reactivity Sumatran orangutan :100 %,   Human :100 %,   Mouse :90 %,   Rat :90 %,   African clawed frog :90 %,   Bovine :80 %,   Zebrafish :70 %,   Green puffer :70 %,  
Characteristics This is a rabbit polyclonal antibody against ZEB2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ZFHX1B
Background The ZFHX1B gene is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. ZFHX1B is strongly transcribed at an early stage in the developing peripheral and central nervous systems of both mice and humans, in all neuronal regions of the brains of 25-week human fetuses and adult mice, and in numerous nonneural tissues.The SMADIP1 gene (also known as SIP1) is a member of the delta-EF1 (ZEB1, MIM 189909)/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SMADIP1 interacts with receptor-mediated, activated full-length SMADs (see MIM 605568) (Verschueren et al., 1999 [PubMed 10400677]).
Molecular Weight 136 kDa
Gene ID 9839
NCBI Accession NP_055610, NM_014795
UniProt O60315
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1214 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Zinc Finger E-Box Binding Homeobox 2 (ZEB2) (N-Term) antibody WB Suggested Anti-ZFHX1B Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human brain
anti-Zinc Finger E-Box Binding Homeobox 2 (ZEB2) (N-Term) antibody (2) Sample Type: Embryonic Spinal CordDilution: 1:200
Background publications Miyoshi, Kitajima, Sumi et al.: "Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells." in: British journal of cancer, Vol. 90, Issue 6, pp. 1265-73, 2004 (PubMed).

General Verstappen, van Grunsven, Michiels et al.: "Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex." in: Human molecular genetics, Vol. 17, Issue 8, pp. 1175-83, 2008 (PubMed).

Validation Images
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