BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (C-Term) antibody

Details for Product No. ABIN183588
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Antigen
Synonyms zgc:112205, BACH1, 6230421P05Rik, AI323795, BACH-1
Epitope
C-Term
(10), (8), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(53), (8), (5), (2)
Host
Rabbit
(38), (10), (5), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(52), (30), (10), (7), (5), (2), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN183588
229.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human BACH1
Sequence PPCARGNSEP GYARGQESQQ MSTATSEQAG PAEQCRQSGG ISDFCQQMTD
Predicted Reactivity Human : 100 %, Rabbit : 80 %
Characteristics This is a rabbit polyclonal antibody against BACH1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name BACH1
Background BACH1 is a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.
Molecular Weight 82 kDa
Gene ID 571
NCBI Accession NM_001186, NP_001177
UniProt O14867
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 736 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) (C-Term) antibody WB Suggested Anti-BACH1 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:1562500
Positive Control: Jurkat cell lysate
Background publications Litman, Peng, Jin et al.: "BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ." in: Cancer cell, Vol. 8, Issue 3, pp. 255-65, 2005 (PubMed).

Validation Images
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