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Details for Product No. ABIN183606

Early Growth Response 4 (EGR4) (C-Term) antibody

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Synonyms NGFIC, NGFI-C, PAT133, NGF1-C, pAT133, Egr4l1, EGR4
»Alternatives C-Term
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Danio rerio), Fruit Fly (Drosophila melanogaster), Human, Chicken
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN183606
Quantity 50 µg
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-EGR4 antibody: synthetic peptide directed towards the C terminal of human EGR4
Predicted Reactivity Bovine : 100%, Chicken : 100%, Dog : 100%, Guinea pig : 100%, Horse : 100%, Human : 100%, Mouse : 100%, Pig : 100%, Rabbit : 100%, Rat : 100%
Characteristics This is a rabbit polyclonal antibody against EGR4. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name EGR4
Background The nerve growth factor-induced clone C (NGFI-C/EGR4) gene is a zinc-finger transcription factor that is rapidly induced by nerve growth factor in rat pheochromocytoma PC12 cells and by seizure in brain. NGFI-C/EGR4 is closely related to the previously described early response genes, nerve growth factor-induced clone A (NGFI-A or EGR1), EGR2, and EGR3. These four early response (immediate early) proteins all contain very similar zinc-finger DNA binding domains and five highly homologous subdomains. EGR-4 functionally cooperate with NFAT proteins and induce expression of IL-2 and TNFalpha. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.
Molecular Weight 51kDa
Gene ID 1961
NCBI Accession NP_001956, NM_001965
UniProt Q05215
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-EGR4 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Decker, Nehmann, Kampen et al.: "Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression." in: Nucleic acids research, Vol. 31, Issue 3, pp. 911-21, 2003 (PubMed).

Alternatives for antigen "Early Growth Response 4 (EGR4)", type "Antibodies"
Hosts (6), (4)
Reactivities (9)
Applications (9), (4), (2), (1)
Epitopes (3), (1)