Early Growth Response 4 (EGR4) (C-Term) antibody

Details for Product No. ABIN183606
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Antigen
Synonyms EGR4, NGFI-C, NGFIC, PAT133, NGF1-C, pAT133, Egr4l1
Epitope
C-Term
(4), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Danio rerio), Fruit Fly (Drosophila melanogaster), Human, Chicken
(11), (2), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(6), (6)
Clonality
Polyclonal
Application
Western Blotting (WB)
(12), (5), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 50 μg
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Catalog No. ABIN183606
289.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human EGR4
Sequence RSDHLTSHVR THTGEKPFAC DVCGRRFARS DEKKRHSKVH LKQKARAEER
Predicted Reactivity Bovine : 100 %, Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %
Characteristics This is a rabbit polyclonal antibody against EGR4. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name EGR4
Background The nerve growth factor-induced clone C (NGFI-C/EGR4) gene is a zinc-finger transcription factor that is rapidly induced by nerve growth factor in rat pheochromocytoma PC12 cells and by seizure in brain. NGFI-C/EGR4 is closely related to the previously described early response genes, nerve growth factor-induced clone A (NGFI-A or EGR1), EGR2, and EGR3. These four early response (immediate early) proteins all contain very similar zinc-finger DNA binding domains and five highly homologous subdomains. EGR-4 functionally cooperate with NFAT proteins and induce expression of IL-2 and TNFalpha. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.
Molecular Weight 51 kDa
Gene ID 1961
NCBI Accession NP_001956, NM_001965
UniProt Q05215
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 486 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Early Growth Response 4 (EGR4) (C-Term) antibody WB Suggested Anti-EGR4 Antibody Titration: 0.0625ug/ml
ELISA Titer: 1:312500
Positive Control: Jurkat cell lysate
anti-Early Growth Response 4 (EGR4) (C-Term) antibody (2) WB Suggested Anti-EGR4
Antibody Titration: 0.0625 µg/mL ELISA Titer: 1:.12500
Positive Control: Jurkat cell lysate
Background publications Decker, Nehmann, Kampen et al.: "Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression." in: Nucleic acids research, Vol. 31, Issue 3, pp. 911-21, 2003 (PubMed).

Validation Images
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