Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) (N-Term) antibody

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Antigen
Synonyms
ZFP36, ttp, C3H-1, g0s24, gos24, tis11, nup475, rnf162a, 2610110L04Rik, AA792898, AU022812, ZNF230, c3h-1, G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36, Tis11, Gos24, Nup475, TIS11D, TISII, Ttp,  ... show more
ZFP36, ttp, C3H-1, g0s24, gos24, tis11, nup475, rnf162a, 2610110L04Rik, AA792898, AU022812, ZNF230, c3h-1, G0S24, GOS24, NUP475, RNF162A, TIS11, TTP, zfp-36, Tis11, Gos24, Nup475, TIS11D, TISII, Ttp, Zfp-36 show less
Epitope
N-Term
(14), (11), (6), (6), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(76), (9), (6), (4), (3), (3), (2), (2), (2), (1)
Host
Rabbit
(48), (28)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(68), (27), (26), (14), (9), (6), (2), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human ZFP36
Blocking Peptide Blocking peptide for this product available: Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) peptide (ABIN986433)
Sequence MDLTAIYESL LSLSPDVPVP SDHGGTESSP GWGSSGPWSL SPSDSSPSGV
Predicted Reactivity Human :100 %,  
Characteristics This is a rabbit polyclonal antibody against ZFP36. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ZFP36 (ZFP36 Antibody Abstract)
Background ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
Molecular Weight 34 kDa
Gene ID 7538
NCBI Accession NP_003398, NM_003407
UniProt P26651
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 326 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) (N-Term) antibody (ABIN183636) anti-Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36) (N-Term) antibody
Background publications Cao, Deterding, Venable et al.: "Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis." in: The Biochemical journal, Vol. 394, Issue Pt 1, pp. 285-97, 2006 (PubMed).

Catalog No. ABIN183636
$289.00
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