Transcription Factor EB (TFEB) (C-Term) antibody

Details for Product No. ABIN183717
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Antigen
Synonyms TFEB, tcfeb, MGC145796, alphatfeb, ALPHATFEB, BHLHE35, TCFEB, Tcfeb, bHLHe35
Epitope
C-Term
(20), (13), (9), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rabbit, Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Danio rerio), Pig (Porcine), Xenopus laevis, Human, Chicken
(96), (35), (21), (17), (14), (14), (1), (1)
Host
Rabbit
(64), (21), (14)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(81), (57), (15), (12), (10), (8), (7), (3), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 100 μg
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Catalog No. ABIN183717
229.00 $
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Immunogen Synthetic peptide directed towards the C terminal of human TFEB
Sequence SLSKKDLDLM LLDDSLLPLA SDPLLSTMSP EASKASSRRS SFSMEEGDVL
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Chicken : 90 %, Goat : 90 %
Characteristics This is a rabbit polyclonal antibody against TFEB. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name TFEB
Background TFEB is a member of the basic Helix-Loop-Helix-Zipper family of transcription factors. TFEB can bind DNA as a homodimer or as a heterodimer with three closely related family members: MITF, TFE3 and TFEC. The t(6,11)(p21,q12), a translocation recently been shown to result in fusion of Alpha, a gene on 11q12, with the transcription factor gene TFEB on 6p21.This translocation ultimately leads to the development of Renal carcinomas.
Molecular Weight 53 kDa
Gene ID 7942
NCBI Accession NM_007162, NP_009093
UniProt P19484
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 476 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Transcription Factor EB (TFEB) (C-Term) antibody WB Suggested Anti-TFEB Antibody Titration: 2.5ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate
anti-Transcription Factor EB (TFEB) (C-Term) antibody (2) WB Suggested Anti-TFEB
Antibody Titration: 2.5 µg/mL ELISA Titer: 1:.12500
Positive Control: HepG2 cell lysate
Background publications Argani, Laé, Hutchinson et al.: "Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR." in: The American journal of surgical pathology, Vol. 29, Issue 2, pp. 230-40, 2005 (PubMed).

Validation Images
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