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Details for Product No. ABIN183717

Transcription Factor EB (TFEB) (C-Term) antibody

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Antigen
Synonyms ALPHATFEB, BHLHE35, TCFEB, Tcfeb, bHLHe35, TFEB, tcfeb, MGC145796, alphatfeb
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Rabbit, Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Danio rerio), Pig (Porcine), Xenopus laevis, Human, Chicken
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN183717
Quantity 100 µg
Price
229.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-TFEB antibody: synthetic peptide directed towards the C terminal of human TFEB
Sequence SLSKKDLDLMLLDDSLLPLASDPLLSTMSPEASKASSRRS SFSMEEGDVL
Predicted Reactivity Bovine : 100%, Dog : 100%, Guinea pig : 100%, Horse : 100%, Human : 100%, Mouse : 100%, Pig : 100%, Rabbit : 100%, Rat : 100%, Chicken : 92%, Goat : 92%
Characteristics This is a rabbit polyclonal antibody against TFEB. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Protein A purified
Alternative Name TFEB
Background TFEB is a member of the basic Helix-Loop-Helix-Zipper family of transcription factors. TFEB can bind DNA as a homodimer or as a heterodimer with three closely related family members: MITF, TFE3 and TFEC. The t(6,11)(p21,q12), a translocation recently been shown to result in fusion of Alpha, a gene on 11q12, with the transcription factor gene TFEB on 6p21.This translocation ultimately leads to the development of Renal carcinomas.
Molecular Weight 53kDa
Gene ID 7942
NCBI Accession NP_009093, NM_007162
UniProt P19484
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-TFEB antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Argani, Laé, Hutchinson et al.: "Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR." in: The American journal of surgical pathology, Vol. 29, Issue 2, pp. 230-40, 2005 (PubMed).

Alternatives for antigen "Transcription Factor EB (TFEB)", type "Antibodies"
Hosts (49), (15), (10)
Reactivities (69), (31), (22), (18), (15), (14), (2), (1), (1)
Applications (54), (39), (11), (10), (10), (6), (3), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (7), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
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