anti-LRP6 antibody (Low Density Lipoprotein Receptor-Related Protein 6) (Internal Region)

Details for Product anti-LRP6 Antibody No. ABIN185307
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Synonyms lrp6-A, Xlrp6, adcad2, lrp6, LRP6, ADCAD2, C030016K15Rik, Cd, Gw
Internal Region
(13), (12), (12), (9), (6), (5), (2), (1), (1), (1), (1), (1), (1), (1)
(67), (17), (4), (3), (1), (1), (1), (1), (1)
(54), (13), (1)
This LRP6 antibody is un-conjugated
(3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Methode Type Peptide ELISA
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(32), (30), (21), (19), (10), (10), (4), (3), (2), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 100 μg
Shipping to United States ( )
Availability Available
Immunogen Peptide with sequence CMTSVATAKGYTSDL, from the internal region of the protein sequence according to NP_002327.2.
Specificity This antibody is expected to recognise an epitope corresponding to aa 1546-1560 of human LRP6 protein.
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine)
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Alternative Name LRP6 (LRP6 Antibody Abstract)
Background Synonyms: LRP6, low density lipoprotein receptor-related protein 6, low density lipoprotein-related protein 6
Gene ID 4040, 16974
NCBI Accession NP_002327
Research Area Stem Cells, Wnt
Pathways WNT Signaling
Application Notes ELISA: antibody detection limit dilution 1:64000.
Western blot: Preliminary experiments gave bands at approx 50 kDa and 35 kDa in Human Adipose lysates after 0.1 µg/mL antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 180 kDa according to NP_002327.2. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
IHC: In paraffin embedded Human Kidney shows luminar membrane staining in DCT. Recommended concentration: 4-6 µg/mL.
Restrictions For Research Use only
Format Liquid
Buffer Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Minimize freezing and thawing.
Storage -20 °C
Storage Comment Aliquot and store at -20 °C.
Supplier Images
Immunohistochemistry (IHC) image for anti-LRP6 antibody (Low Density Lipoprotein Receptor-Related Protein 6) (Internal Region) (ABIN185307) ABIN185307 (5µg/ml) staining of paraffin embedded human liver. Steamed antigen retrie...
Background publications Giles, van Es, Clevers: "Caught up in a Wnt storm: Wnt signaling in cancer." in: Biochimica et biophysica acta, Vol. 1653, Issue 1, pp. 1-24, 2003 (PubMed).

Tamai, Semenov, Kato et al.: "LDL-receptor-related proteins in Wnt signal transduction." in: Nature, Vol. 407, Issue 6803, pp. 530-5, 2000 (PubMed).

Catalog No. ABIN185307
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