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Details for Product No. ABIN192135

CD48 Molecule (CD48) antibody (APC)

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Antigen
Synonyms BCM1, BLAST, hCD48, mCD48, BLAST1, SLAMF2, MEM-102, Bcm-1, Sgp-60, BLAST-1, AI449234, AW610730
Reactivity
»Alternatives Human, Primate
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
Application
»Alternatives Flow Cytometry (FACS)
Pubmed 5 references available
Catalog no. ABIN192135
Quantity 100 tests
Price
421.08 $   Plus shipping costs $45.00
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Availability Will be delivered in 4 to 5 Business Days
Immunogen Raji human Burkitt's lymphoma cell line
Clone MEM-102
Isotype IgG1
Specificity The antibody MEM-102 reacts with CD48 antigen (Blast-1), a 40-47 kDa GPI-anchoredmembrane protein (immunoglobulin supergene family) widely expressed on hematopoieticcells, it is negative on granulocytes, platelets and erythrocytes.HLDA V, WS Code AS S014
Alternative Name CD48
Background CD48 (Blast-1) belongs to the CD2 subset of the Ig superfamily, which includes CD2,CD2F-10, CD58, CD84, CD150, CD229, CD244 and others. These molecules bind to thesame or another members of their family, thus mediate homotypic or heterotypic adhesion.CD48 is a GPI-anchored protein broadly expressed on hematopoietic cells and serves as ahigh affinity ligand for 2B4 and low affinity ligand for CD2. 2B4-CD48 interaction among NKcells and NK-T cells regulates cell proliferation. Signaling through CD48 results in eosinophilactivation and CD48 expression is increased in several infectious diseases.
Gene ID 962
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes The reagent is designed for Flow Cytometry analysis of human blood cells using 10 µl reagent / 100 µl of whole blood or 10 6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Restrictions For Research Use only
Buffer The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azideand 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Preservative Sodium azide
Storage 4 °C
Korínek, Stefanová, Angelisová et al.: "The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1." in: Immunogenetics, Vol. 33, Issue 2, pp. 108-12, 1991 (PubMed).

Bazil, Stefanová, Hilgert et al.: "Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102." in: Folia biologica, Vol. 35, Issue 5, pp. 289-97, 1990 (PubMed).

Angelisová, Drbal, Horejsí et al.: "Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase." in: Blood, Vol. 93, Issue 4, pp. 1437-9, 1999 (PubMed).

Drbal, Moertelmaier, Holzhauser et al.: "Single-molecule microscopy reveals heterogeneous dynamics of lipid raft components upon TCR engagement." in: International immunology, Vol. 19, Issue 5, pp. 675-84, 2007 (PubMed).

Carlsten, Baumann, Simonsson et al.: "Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34(+) blasts in myelodysplastic syndrome." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, 2010 (PubMed).

Alternatives for antigen "CD48 Molecule (CD48)", type "Antibodies"
Hosts (108), (34), (33), (29), (1)
Reactivities (103), (84), (41), (14), (12), (12), (5)
Applications (157), (56), (31), (27), (24), (10), (6), (5), (5), (4), (3), (3), (2), (1)
Conjugates (32), (26), (18), (10), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (2), (2), (1), (1), (1)
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