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Ezrin (EZR) (Tyr 353) antibody

Details for Product No. ABIN197258
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Antigen
Synonyms ezr, vil2, wu:fc05c03, wu:fj31d06, cvil, cvl, CVIL, CVL, VIL2, AW146364, R75297, Vil2, p81, ATVLN2, T11A7.16, T11A7_16, villin 2
Epitope
Tyr 353
(32), (26), (23), (21), (17), (15), (12), (6), (5), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(257), (181), (158), (52), (38), (36), (36), (12), (2), (2), (1)
Host
Rabbit
(225), (22), (10), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5)
Application
Western Blotting (WB)
(208), (91), (50), (47), (33), (16), (6), (4), (4), (3), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN197258
308.00 $
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Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human Ezrin around the phosphorylation site of tyrosine 353 (Q-D-YP-E-E).
Specificity Ezrin antibody detects endogenous levels of total Ezrin protein.
Purification Affinity-chromatography using epitope-specific immunogen
Alternative Name Ezrin
Background Ezrin (also known as p81, 80K, or cytovillin) is a cytoplasmic protein which is enriched in microvilli and other cell surface structures. Its NH2-terminal domain is associated with the plasma membrane and the COOH-terminal domain with the cytoskeleton. Ezrin has an actin-binding capability. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas. Ezrin serves as a tyrosine kinase substrate, and is phosphorylated in EGF-stimulated cells.
Alternate names: Cytovillin, EZR, VIL2, Villin-2, p81
Gene ID 7430
NCBI Accession NP_001104547.1
UniProt P15311
Research Area Cancer, Cytoskeleton, Microfilaments
Application Notes Western Blot: 1: 500~1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS(without Mg2+ and Ca2+), pH 7.4 containing 150mM NaCl, 0.02% sodium azide and 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Expiry Date 12 months
Supplier Images
anti-Ezrin (EZR) (Tyr 353) antibody anti-Ezrin (EZR) (Tyr 353) antibody
Background publications Crepaldi, Gautreau, Comoglio et al.: "Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells." in: The Journal of cell biology, Vol. 138, Issue 2, pp. 423-34, 1997 (PubMed).

Gautreau, Poullet, Louvard et al.: "Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 13, pp. 7300-5, 1999 (PubMed).

Wang, Pfeiffer, Gaarde: "Activation of SRC tyrosine kinases in response to ICAM-1 ligation in pulmonary microvascular endothelial cells." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47731-43, 2003 (PubMed).

Zhao, Shiue, Palkon et al.: "Ezrin regulates NHE3 translocation and activation after Na+-glucose cotransport." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 25, pp. 9485-90, 2004 (PubMed).

Validation Images
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