Low Density Lipoprotein Receptor-Related Protein (LRP), 85 kDa antibody

Details for Product No. ABIN235783, Supplier: Log in to see
Clonality (Clone)
Monoclonal ()
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Clone 5A6
Isotype IgG2b
Specificity Reacts with human, rabbit and mouse LRP. Will not block ligand binding. Recognizes an epitope in the extracellular domain when tested in flow cytometry.
Characteristics MAb to Low Density LRP (85 kDa), Monoclonal antibody to Human Low Density Lipoprotein Receptor-Related Protein (LRP), 85 kDa
Purification Produced in VLDL receptor knockout mice. Protein A Chromatography.
Application Notes ELISA (1:10.000) Western blot using non-reducing conditions at 1-5 µg/mL Immunohistochemistry using paraffin and frozen sections at 1-10 µg/mL Flow cytometry Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.
Restrictions For Research Use only
Format Liquid
Buffer 0.05 M Sodium phosphate, 0.5 M Sodium chloride, 1 mM EDTA, pH 6.6.
Preservative Without preservative
Storage -80 °C
Storage Comment Store (up to 1 year) at -70 °C.
Expiry Date 12 months
Background publications Coukos, Gåfvels, Wisel, Ruelaz, Strickland, Strauss, Coutifaris: "Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts." in: The American journal of pathology, Vol. 144, Issue 2, pp. 383-92, 1994 (PubMed).

Rebeck, Reiter, Strickland, Hyman: "Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions." in: Neuron, Vol. 11, Issue 4, pp. 575-80, 1993 (PubMed).

Strickland, Ashcom, Williams, Burgess, Migliorini, Argraves: "Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor." in: The Journal of biological chemistry, Vol. 265, Issue 29, pp. 17401-4, 1990 (PubMed).