DAND5 antibody (AA 23-189)

Catalog No. ABIN2719204

Product Details anti-DAND5 Antibody

Target: DAND5 (DAN Domain Family, Member 5 (DAND5))

Binding Specificity: AA 23-189

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DAND5 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Characteristics: Homo sapiens DAN domain family, member 5 (DAND5)

Purification: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Human recombinant protein fragment corresponding to amino acids 23-189 of human DAND5(NP_689867) produced in E.coli.

Clone: 3A3

Isotype: IgG2a

Application Details

Application Notes: IF 1:100, FLOW 1:100,

Comment:

The concentration of the product may vary between diferrent lots.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for DAND5

Target: DAND5 (DAN Domain Family, Member 5 (DAND5))

Alternative Name: DAND5 (DAND5 Products)

Background: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

Molecular Weight: 18 kDa

Gene ID: 199699

NCBI Accession: NM_152654

HGNC: 199699