IL-17 antibody

Catalog No. ABIN2474946

Product Details anti-IL-17 Antibody

Target: IL-17 (IL17) (Interleukin 17 (IL17))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL-17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Specificity: This antibody recognises mouse Interleukin 17, a 32 kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family (classified as IL-17A to IL-17F), and signal through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.

Characteristics: Purified IgG

Purification: Purified

Clone: TC11-18H10

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Target Details for IL-17

Target: IL-17 (IL17) (Interleukin 17 (IL17))

Alternative Name: IL-17 (IL17 Products)

Background: Synonyms: IL-17A