PTGES3 antibody
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- Target See all PTGES3 Antibodies
- PTGES3 (Prostaglandin E Synthase 3 (Cytosolic) (PTGES3))
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Reactivity
- Human, Mouse, Guinea Pig, Rabbit, Chicken, Saccharomyces cerevisiae
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This PTGES3 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Enzyme Immunoassay (EIA)
- Specificity
- This antibody detects ~23 kDa p23.
- Characteristics
- Synonyms: Prostaglandin E synthase 3, cPGES, P23, Cytosolic prostaglandin E2 synthase,Telomerase-binding protein p23, Hsp90 co-chaperone, Progesterone receptor complex p23
- Purification
- Protein G Affinity Chromatography
- Immunogen
- Recombinant Human full length p23 protein
- Clone
- JJ6
- Isotype
- IgG1
- Top Product
- Discover our top product PTGES3 Primary Antibody
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- Application Notes
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Western blot (1: 2000). Immunprecipitation. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS in 50 % Glycerol, 0.09 % Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
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Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch. - Expiry Date
- 12 months
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- Target
- PTGES3 (Prostaglandin E Synthase 3 (Cytosolic) (PTGES3))
- Alternative Name
- PTGES3 / TEBP (PTGES3 Products)
- Background
- P23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the hsp90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with hsp70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated hsp90 binding of client proteins (8). Since many hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.Synonyms: Cytosolic prostaglandin E2 synthase, Hsp90 co-chaperone, P23, Progesterone receptor complex p23, Prostaglandin E synthase 3, Telomerase-binding protein p23, cPGES
- Gene ID
- 10728
- UniProt
- Q15185
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Cellular Glucan Metabolic Process
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