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Prostaglandin E Synthase 3 (Cytosolic) (PTGES3) antibody

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Antigen
Synonyms P23, TEBP, cPGES, 5730442A20Rik, Ptges, Tebp, p23, sid3177, PTGES3, RGD1561913, CPGES, DKFZp459H1920
Reactivity
»Alternatives Chicken, Guinea Pig, Human, Mouse (Murine), Rabbit, Yeast (Saccharomyces cerevisiae)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ( )
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 8 references available
Catalog no. ABIN263974
Quantity 0.1 mg  (Variants)
Price
302.50 $   Plus shipping costs $45.00
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anti-Prostaglandin E Synthase 3 (Cytosolic) (PTGES3) antibody

Product details

Target Details Application Details Handling Images References Alternatives Variants back to top
Immunogen Recombinant Human full length p23 protein
Clone
Isotype IgG1
Characteristics Synonyms: Prostaglandin E synthase 3, cPGES, P23, Cytosolic prostaglandin E2 synthase,Telomerase-binding protein p23, Hsp90 co-chaperone, Progesterone receptor complex p23
Purification Protein G Affinity Chromatography

Target Details

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Alternative Name PTGES3 / TEBP
Background P23 is a highly conserved ubiquitous protein, known to have an important function as acochaperone for the hsp90 chaperoning system (1). Studies have revealed that p23 is asmall protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structuralhomology with any other known proteins (1). p23 was first discovered as a part of theHsp90-progesterone receptor complex along with hsp70, p54 and p50 (1). p23 is aphosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain(1). Numerous studies have found p23 to be associated with other client proteins like Festyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), arylhydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). Inspite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate-mediated hsp90 binding ofclient proteins (8). Since many hsp90 client proteins are involved in oncogenic survivalsignaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis(9). Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targetsin oncology.
UniProt Q15185

Application Details

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Application Notes Western blot (1: 2000). Immunprecipitation. ELISA. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

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Format Liquid
Concentration 1.0 mg/mL
Buffer PBS in 50% Glycerol 0.09% Sodium Azide
Preservative Sodium azide
Storage 2-8 °C
Storage Comment Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months

References

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Background publications Johnson, Beito, Krco et al.: "Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes." in: Molecular and cellular biology, Vol. 14, Issue 3, pp. 1956-63, 1994 (PubMed).

Pingoud, Jeltsch: "Recognition and cleavage of DNA by type-II restriction endonucleases." in: European journal of biochemistry / FEBS, Vol. 246, Issue 1, pp. 1-22, 1997 (PubMed).

Nair, Toran, Rimerman et al.: "A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor." in: Cell stress & chaperones, Vol. 1, Issue 4, pp. 237-50, 1997 (PubMed).

Holt, Aisner, Baur et al.: "Functional requirement of p23 and Hsp90 in telomerase complexes." in: Genes & development, Vol. 13, Issue 7, pp. 817-26, 1999 (PubMed).

Weikl, Abelmann, Buchner: "An unstructured C-terminal region of the Hsp90 co-chaperone p23 is important for its chaperone function." in: Journal of molecular biology, Vol. 293, Issue 3, pp. 685-91, 1999 (PubMed).

Weaver, Sullivan, Felts et al.: "Crystal structure and activity of human p23, a heat shock protein 90 co-chaperone." in: The Journal of biological chemistry, Vol. 275, Issue 30, pp. 23045-52, 2000 (PubMed).

Hu, Toft, Anselmo et al.: "In vitro reconstitution of functional hepadnavirus reverse transcriptase with cellular chaperone proteins." in: Journal of virology, Vol. 76, Issue 1, pp. 269-79, 2001 (PubMed).

Felts, Toft: "p23, a simple protein with complex activities." in: Cell stress & chaperones, Vol. 8, Issue 2, pp. 108-13, 2003 (PubMed).

Alternatives

Target Details Application Details Handling Images References Variants back to top
Alternatives for antigen "Prostaglandin E Synthase 3 (Cytosolic) (PTGES3)", type "Antibodies"
Hosts (40), (6)
Reactivities (45), (21), (21), (19), (17), (17), (17), (17), (2), (2), (1)
Applications (31), (19), (14), (9), (7), (3), (2), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (3), (2), (1), (1), (1), (1)
Beacon
Guglhupf
Guglhupf Guglhupf Guglhupf