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Integrin alpha-L (ITGAL) antibody

Details for Product No. ABIN264310
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Antigen
Synonyms (p180), Cd11a, LFA-1, LFA-1A, Ly-15, Ly-21, CD11A, LFA1A, CD11a
Reactivity
Human
(206), (154), (44), (30), (25), (25), (9), (4), (1), (1)
Host
Mouse
(246), (124), (34), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(79), (48), (41), (18), (8), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(333), (101), (58), (47), (43), (35), (17), (14), (14), (13), (13), (12), (7), (3), (3), (1), (1), (1), (1)
Pubmed 7 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

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Catalog No. ABIN264310
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Clone OFYS
Isotype IgG2a
Characteristics Synonyms: Integrin alpha-L, LFA1, LFA-1, Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocytefunction-associated molecule 1 alpha chain, CD11 antigen-like family member A
Purification Purified
Alternative Name CD11a / ITGAL
Background CD11a, Leukocyte Function Antigen-1 (LFA-1) complex is a heterodimeric glycoproteinconsisting of two non-covalently linked chains, a 180 kDa alpha chain and a 95 kDa betachain. It is a member of the integrin supergene family of adhesion molecules, and is onvirtually all peripheral blood leukocytes. The molecule binds to ICAM-1, 2 and 3 andmediates cell-cell adhesion.
UniProt P20701
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry. Characterization of LFA-1 immunodeficiency. Monitoring of subsets in peripheral blood. Graft-versus-host disease. Analysis of CTL-mediated cytotoxicity. Studies of transplantation rejection. Functional studies of cell adhesion molecules. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Protocol PBMC: Add 10 ul of MAB/10e6 PBMC in 100 ul PBS. Mix gently and incubate for 15 minutes at 2-8°C. Wash twice with PBS and analyze or fix with 0. 5% v/v of paraformaldehyde in PBS andanalyze.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.08% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: One year from despatch.
Expiry Date 12 months
Background publications Pedrinaci, Ruiz-Cabello, Gomez et al.: "Protein kinase C-mediated regulation of the expression of CD14 and CD11/CD18 in U937 cells." in: International journal of cancer. Journal international du cancer, Vol. 45, Issue 2, pp. 294-8, 1990 (PubMed).

Heiskala, Patarroyo, Timonen: "Participation of CD11a-c/CD18 and RGD-recognizing adhesion molecules in the binding of LGL to fibroblasts. Evidence for the role of CD11a in the fibroblast-mediated inactivation of NK cells." in: Scandinavian journal of immunology, Vol. 32, Issue 2, pp. 137-47, 1990 (PubMed).

Hartnell, Moqbel, Walsh et al.: "Fc gamma and CD11/CD18 receptor expression on normal density and low density human eosinophils." in: Immunology, Vol. 69, Issue 2, pp. 264-70, 1990 (PubMed).

Arnaout: "Leukocyte adhesion molecules deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response." in: Immunological reviews, Vol. 114, pp. 145-80, 1990 (PubMed).

Patarroyo, Prieto, Rincon et al.: "Leukocyte-cell adhesion: a molecular process fundamental in leukocyte physiology." in: Immunological reviews, Vol. 114, pp. 67-108, 1990 (PubMed).

van Dijken, Ghayur, Mauch et al.: "Evidence that anti-LFA-1 in vivo improves engraftment and survival after allogeneic bone marrow transplantation." in: Transplantation, Vol. 49, Issue 5, pp. 882-6, 1990 (PubMed).

Anderson, Springer: "Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins." in: Annual review of medicine, Vol. 38, pp. 175-94, 1987 (PubMed).

Validation Images
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