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C-C Chemokine Receptor Type 5 (CCR5) (AA 6-20) antibody

Details for Product No. ABIN265000
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Antigen
Synonyms AM4-7, CD195, Cmkbr5, Ckr5, CC-CKR-5, CCR-5, CMKBR5, GPCR, CCR5, CCCKR5, CKR-5, CKR5, IDDM22
Epitope
AA 6-20
(14), (14), (14), (9), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(199), (61), (38), (1), (1)
Host
Rabbit
(118), (46), (43), (15), (7), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(18), (13), (13), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(119), (102), (76), (29), (24), (18), (16), (13), (10), (5), (2), (1), (1)
Pubmed 8 references available
Quantity 0.1 mg
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Catalog No. ABIN265000
368.50 $
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Immunogen Synthetic peptide corresponding to amino acids 6 to 20 of Human CCR5.
Isotype IgG
Specificity This antibody reacts to CCR5 (6-20) (CD195).
Purification Antigen Immunoaffiinity Chromatography
Alternative Name CD195 / CCR5
Background Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors1,2. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells3,4. CCR5 is required for the infection by HIV-1, HIV-2, and SIV1,2. The b-chemokines RANTES, MIP-1a and MIP-1b are the ligands for CCR5 and prevent infection by M-tropic HIV-13-5. CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells6,7. The amino- terminal domain and the extracellular loops of CCR5 serve as HIV biding sites8. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
Alternate names: C-C CKR-5, C-C chemokine receptor type 5, CC-CKR-5, CCR-5, CHEMR13, CMKBR5, HIV-1 fusion coreceptor
Gene ID 1234
NCBI Accession NP_000570.1
UniProt P51681
Research Area CD Antigens, Surface Receptors of Immune Cells, Chemokines, Receptors
Application Notes Western Blot: 0.25 to 0.5 ug/ml. Detects an approximately 40 kDa band in THP-1 whole celllysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline solution containing 0.02% Sodium Azide as a preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at 2-8°C.
Expiry Date 12 months
Supplier Images
anti-C-C Chemokine Receptor Type 5 (CCR5) (AA 6-20) antibody anti-C-C Chemokine Receptor Type 5 (CCR5) (AA 6-20) antibody
Background publications Cocchi, DeVico, Garzino-Demo et al.: "Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells." in: Science (New York, N.Y.), Vol. 270, Issue 5243, pp. 1811-5, 1996 (PubMed).

Deng, Liu, Ellmeier et al.: "Identification of a major co-receptor for primary isolates of HIV-1." in: Nature, Vol. 381, Issue 6584, pp. 661-6, 1996 (PubMed).

Dragic, Litwin, Allaway et al.: "HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5." in: Nature, Vol. 381, Issue 6584, pp. 667-73, 1996 (PubMed).

Wu, Gerard, Wyatt et al.: "CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5." in: Nature, Vol. 384, Issue 6605, pp. 179-83, 1996 (PubMed).

Trkola, Dragic, Arthos et al.: "CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5." in: Nature, Vol. 384, Issue 6605, pp. 184-7, 1996 (PubMed).

Doranz, Lu, Rucker et al.: "Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1." in: Journal of virology, Vol. 71, Issue 9, pp. 6305-14, 1997 (PubMed).

Dimitrov: "How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity." in: Cell, Vol. 91, Issue 6, pp. 721-30, 1998 (PubMed).

Littman: "Chemokine receptors: keys to AIDS pathogenesis?" in: Cell, Vol. 93, Issue 5, pp. 677-80, 1998 (PubMed).

Validation Images
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