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Visual System Homeobox 2 (VSX2) (AA 1-131), (N-Term) antibody

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Synonyms VSX2, CHX10, c-ret, cret, etID315074.13, ret1, wu:fd13h01, HOX10, MCOP2, MCOPCB3, RET1, Chx10, Hox-10, Hox10, or, Vsx-2, alx, chx10
N-Term, AA 1-131
(26), (16), (12), (7), (2), (2), (1), (1), (1), (1), (1)
Mouse (Murine), Rat (Rattus)
(38), (15), (12), (9), (3), (1)
(55), (8), (1)
(8), (5), (2), (2), (2), (2), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(48), (33), (4), (4), (4), (3), (2), (2), (1)
Pubmed 12 references available
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Quantity 0.25 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Antibody raised against a recombinant protein corresponding to amino acids 1 to 131 derived from the N terminal of the human Chx10 protein conjugated to GST.
Isotype IgG
Specificity This antibody recognizes chx 10 (N-Term).
Purification Purified
Alternative Name VSX2 / CHX10 (VSX2 Antibody Abstract)
Background Chx10 is a 46 kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.Synonyms: Ceh-10 homeodomain-containing homolog, HOX10, Homeobox protein CHX10, Visual system homeobox 2
Molecular Weight 46 kDa
Gene ID 12677
NCBI Accession NP_031727
UniProt Q61412
Application Notes Western Blot: 0.5-1.0 mg/mL. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Immunohistochemistry on Frozen Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.08 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Can be shipped at ambient temperature.
Supplier Images
Image no. 1 for anti-Visual System Homeobox 2 (VSX2) (AA 1-131), (N-Term) antibody (ABIN265011) anti-Visual System Homeobox 2 (VSX2) (AA 1-131), (N-Term) antibody
Product cited in: Bai, Kiyama, Li et al.: "Birth of cone bipolar cells, but not rod bipolar cells, is associated with existing RGCs." in: PLoS ONE, Vol. 9, Issue 1, pp. e83686, 2014 (PubMed).

Haynes, Luz-Madrigal, Reis et al.: "Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration." in: Nature communications, Vol. 4, pp. 2312, 2013 (PubMed).

Tiwari, Hudson, Gattone et al.: "Meckelin 3 is necessary for photoreceptor outer segment development in rat Meckel syndrome." in: PLoS ONE, Vol. 8, Issue 3, pp. e59306, 2013 (PubMed).

Nittner, Lambertz, Clermont et al.: "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." in: Nature cell biology, Vol. 14, Issue 9, pp. 958-65, 2012 (PubMed).

Sherry, Kanan, Hamilton et al.: "Differential developmental deficits in retinal function in the absence of either protein tyrosine sulfotransferase-1 or -2." in: PLoS ONE, Vol. 7, Issue 6, pp. e39702, 2012 (PubMed).

Wakabayashi, Kosaka, Mori et al.: "Prolonged expression of Puma in cholinergic amacrine cells during the development of rat retina." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 60, Issue 10, pp. 777-88, 2012 (PubMed).

Luo, Jin, Xie et al.: "Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 9, pp. E553-62, 2012 (PubMed).

Elshatory, Everhart, Deng et al.: "Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 46, pp. 12707-20, 2007 (PubMed).

Osakada, Ooto, Akagi et al.: "Wnt signaling promotes regeneration in the retina of adult mammals." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 15, pp. 4210-9, 2007 (PubMed).

Background publications Ferda Percin, Ploder, Yu et al.: "Human microphthalmia associated with mutations in the retinal homeobox gene CHX10." in: Nature genetics, Vol. 25, Issue 4, pp. 397-401, 2000 (PubMed).

Chen, Cepko: "Expression of Chx10 and Chx10-1 in the developing chicken retina." in: Mechanisms of development, Vol. 90, Issue 2, pp. 293-7, 2000 (PubMed).

Liu, Chen, Ploder et al.: "Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer." in: Neuron, Vol. 13, Issue 2, pp. 377-93, 1994 (PubMed).

Catalog No. ABIN265011
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