Ets Variant 5 (ETV5) (N-Term) antibody

Details for Product No. ABIN309622
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Antigen
Synonyms ERM, etv5, fj87h10, id:ibd5133, wu:fj87h10, zgc:55647, 1110005E01Rik, 8430401F14Rik
Epitope
N-Term
(22), (9), (9), (8), (3), (2), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Cow (Bovine), Dog (Canine), Zebrafish (Danio rerio), Human
(69), (18), (18), (14), (14), (12), (2), (1), (1)
Host
Rabbit
(41), (28)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(57), (35), (10), (10), (7), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN309622
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human ETV5
Sequence MDGFYDQQVPFMVPGKSRSEECRGRPVIDRKRKFLDTDLA HDSEELFQDL
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Rabbit : 100 %, Rat : 90 %, Mouse : 90 %, Chicken : 80 %
Characteristics This is a rabbit polyclonal antibody against ETV5. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name ETV5
Background ETV5 Contains 1 ETS DNA-binding domain and belongs to the ETS family. The ETV5 gene expression is regulated by the conventional PKC (cPKC) pathway.ETV5 is subject to SUMO modification and this post-translational modification causes inhibition of transcription-enhancing activity Phosphorylated ETV5 and the actin cytoskeleton regulate CD44-mediated hyaluronan binding in myeloid cells. ERMs (ezrin/radixin/moesin) function as adaptor molecules in the interactions of adhesion receptors and intracellular tyrosine kinases. ETV5 can cooperate with c-Jun and has a role in progression of breast cancer.
Molecular Weight 58 kDa
Gene ID 2119
NCBI Accession NM_004454, NP_004445
UniProt P41161
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 510 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Ets Variant 5 (ETV5) (N-Term) antibody WB Suggested Anti-ETV5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:7812500
Positive Control: Human Lung
anti-Ets Variant 5 (ETV5) (N-Term) antibody (2) Immunohistochemistry with Spleen tissue at an antibody concentration of 5µg/ml using anti-ETV5 antibody (ARP31658_P050)
anti-Ets Variant 5 (ETV5) (N-Term) antibody (3) WB Suggested Anti-ETV5
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.812500
Positive Control: Human Lung
Background publications Helgeson, Tomlins, Shah et al.: "Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer." in: Cancer research, Vol. 68, Issue 1, pp. 73-80, 2008 (PubMed).

Validation Images
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