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Details for Product No. ABIN309654

RuvB-Like 1 (E. Coli) (RUVBL1) (N-Term) antibody

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Antigen
Synonyms RVB1, TIH1, ECP54, TIP49, INO80H, NMP238, PONTIN, TIP49A, Pontin52, Tip49a, 2510009G06Rik, pontin, zpontin, wu:fd18e04, tip49, xpontin, pontin52, rvb1, ecp54, nmp238, tip49a
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio), Xenopus laevis, Dog (Canine), Cow (Bovine), Human, Chicken
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN309654
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-RUVBL1 antibody: synthetic peptide directed towards the N terminal of human RUVBL1
Sequence KIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVG QENAREACGV
Predicted Reactivity African clawed frog : 100%, Bovine : 100%, Dog : 100%, Horse : 100%, Human : 100%, Mouse : 100%, Rabbit : 100%, Zebrafish : 100%, Chicken : 92%
Characteristics This is a rabbit polyclonal antibody against RUVBL1. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name RUVBL1
Background RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
Molecular Weight 50kDa
Gene ID 8607
NCBI Accession NP_003698, NM_003707
UniProt Q9Y265
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-RUVBL1 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Jha, Shibata, Dutta: "Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage." in: Molecular and cellular biology, Vol. 28, Issue 8, pp. 2690-700, 2008 (PubMed).

Alternatives for antigen "RuvB-Like 1 (E. Coli) (RUVBL1)", type "Antibodies"
Hosts (13), (11), (1)
Reactivities (24), (4), (4)
Applications (24), (8), (8), (7), (3), (2), (2), (2), (1), (1), (1)
Epitopes (2), (2), (1), (1), (1), (1)
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