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RuvB-Like 1 (E. Coli) (RUVBL1) (N-Term) antibody

Details for Product No. ABIN309654, Supplier: Login to see New
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Synonyms rvb1, ecp54, tip49, nmp238, pontin, tip49a, xpontin, pontin52, TIP49, wu:fd18e04, zpontin, ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49A, Tip49a, 2510009G06Rik
(5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Chicken, Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis, Zebrafish (Danio rerio)
(72), (9), (9)
(44), (27), (1)
(3), (3), (3), (3), (3), (3)
Western Blotting (WB)
(64), (31), (29), (28), (11), (6), (5), (5), (3), (2), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide directed towards the N terminal of human RUVBL1
Blocking Peptide Blocking peptide for this product available: ABIN983335
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Zebrafish : 100 %, Chicken : 90 %
Characteristics This is a rabbit polyclonal antibody against RUVBL1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name RUVBL1 (RUVBL1 Antibody Abstract)
Background RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
Molecular Weight 50 kDa
Gene ID 8607
NCBI Accession NP_003698, NM_003707
UniProt Q9Y265
Pathways Telomere Maintenance
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 456 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-RuvB-Like 1 (E. Coli) (RUVBL1) (N-Term) antibody (ABIN309654) Host: Rabbit
Target Name: RUVBL1
Sample Tissue: Human Fetal Lung
Western Blotting (WB) image for anti-RuvB-Like 1 (E. Coli) (RUVBL1) (N-Term) antibody (ABIN309654) WB Suggested Anti-RUVBL1 Antibody
Positive Control: Lane 1:341 µg K562 lysate ...
Background publications Jha, Shibata, Dutta: "Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage." in: Molecular and cellular biology, Vol. 28, Issue 8, pp. 2690-700, 2008 (PubMed).

Catalog No. ABIN309654
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