RuvB-Like 1 (E. Coli) (RUVBL1) (N-Term) antibody

Details for Product No. ABIN309654
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Antigen
Synonyms rvb1, ecp54, tip49, nmp238, pontin, tip49a, xpontin, pontin52, TIP49, wu:fd18e04, zpontin, ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49A, Tip49a, 2510009G06Rik
Epitope
N-Term
(2), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio), Xenopus laevis, Dog (Canine), Cow (Bovine), Human, Chicken
(33), (2), (2)
Host
Rabbit
(17), (16), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(34), (16), (14), (13), (3), (2), (2), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN309654
289.00 $
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide directed towards the N terminal of human RUVBL1
Sequence KIEEVKSTTK TQRIASHSHV KGLGLDESGL AKQAASGLVG QENAREACGV
Predicted Reactivity African clawed frog : 100 %, Bovine : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Rabbit : 100 %, Zebrafish : 100 %, Chicken : 90 %
Characteristics This is a rabbit polyclonal antibody against RUVBL1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name RUVBL1
Background RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
Molecular Weight 50 kDa
Gene ID 8607
NCBI Accession NP_003698, NM_003707
UniProt Q9Y265
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 456 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (N-Term) antibody Host: Rabbit
Target Name: RUVBL1
Sample Tissue: Human Fetal Lung
Antibody Dilution: 1.0 µg/mL
anti-RuvB-Like 1 (E. Coli) (RUVBL1) (N-Term) antibody (2) WB Suggested Anti-RUVBL1 Antibody
Positive Control: Lane 1:341 µg K562 lysate
Primary Antibody Dilution: 1:000
Secondary Antibody: Anti-rabbit-HRP Secondry
Antibody Dilution: 1:0000
Submitted by: Sustackova Gabriela
Background publications Jha, Shibata, Dutta: "Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage." in: Molecular and cellular biology, Vol. 28, Issue 8, pp. 2690-700, 2008 (PubMed).

Validation Images
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