Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) (C-Term) antibody

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Antigen
Alternatives
Epitope
C-Term
(17), (15), (15), (15), (6), (6), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(108), (18), (12), (5), (4), (2), (1), (1), (1)
Host
Rabbit
(87), (27)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (4), (4), (2), (2), (2)
Application
Western Blotting (WB)
(105), (48), (23), (17), (5), (3), (3), (2), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Quantity 100 μg
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Immunogen Synthetic peptide directed towards the C terminal of human NR1I3
Sequence FHGTLRKLQL QEPEYVLLAA MALFSPDRPG VTQRDEIDQL QEEMALTLQS
Predicted Reactivity Human : 100 %, Mouse : 90 %, Rabbit : 90 %, Rat : 90 %, Guinea pig : 80 %, Dog : 70 %
Characteristics This is a rabbit polyclonal antibody against NR1I3. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Alternative Name NR1I3 (NR1I3 Antibody Abstract)
Background NR1I3 is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members.
Molecular Weight 40 kDa
Gene ID 9970
NCBI Accession NP_005113, NM_005122
UniProt Q5VTW5
Pathways Nuclear Receptor Transcription Pathway
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 348 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) (C-Term) antibody (ABIN309705) WB Suggested Anti-NR1I3 Antibody Titration: 1.25ug/ml
Positive Control: ...
Background publications Ferguson, Chen, LeCluyse et al.: "Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha." in: Molecular pharmacology, Vol. 68, Issue 3, pp. 747-57, 2005 (PubMed).

Catalog No. ABIN309705
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