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Details for Product No. ABIN319276

Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1) (pSer49) antibody

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EIF2, EIF-2, EIF2A, EIF-2A, EIF-2alpha, eif2, eif2s1, fb19d01, wu:fb19d01, eif2a, 35kDa, Eif2a, eIF2alpha, 0910001O23Rik, 2410026C18Rik, CG9946, Dmel\\CG9946, Eif2alpha, IF2A_DROME, M(1)14C, M(1)19-15 ... show more
»Alternatives pSer49
»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 2 references available
Catalog no. ABIN319276
Quantity 50 µg
275.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic phosphopeptide derived from human eIF2a around the phosphorylation site of Serine 49 (L-L-SP-E-L).
Specificity Antibody detects endogenous levels of eIF2a only when phosphorylated at Serine 49.
Purification Affinity Chromatography
Alternative Name EIF2A / EIF2S1
Background The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD), and gamma (52 kD). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha.
Alternate names: EIF2-A, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit alpha, eIF-2-alpha, eIF-2A, eIF-2alpha, eIF2 alpha
Gene ID 1965
NCBI Accession NP_004085.1
UniProt P05198
Application Notes Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide and 50% Glycerol.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20°C.
Expiry Date 12 months
Background publications de Haro, Méndez, Santoyo: "The eIF-2alpha kinases and the control of protein synthesis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 10, Issue 12, pp. 1378-87, 1996 (PubMed).

Kimball: "Eukaryotic initiation factor eIF2." in: The international journal of biochemistry & cell biology, Vol. 31, Issue 1, pp. 25-9, 1999 (PubMed).

Alternatives for antigen "Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1)", type "Antibodies"
Hosts (62), (23), (1)
Reactivities (76), (35), (35), (6), (5), (2), (2), (1), (1), (1), (1)
Applications (75), (37), (24), (21), (15), (11), (6), (3), (2), (2), (1), (1), (1)
Epitopes (12), (5), (5), (5), (5), (5), (3), (2), (2), (2), (2), (1), (1)