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Details for Product No. ABIN349986

Coiled-Coil Myosin-Like BCL2-Interacting Protein (Beclin-1, BECN1, GT197, ATG6, V) antibody

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Human, Rat (Rattus), Mouse (Murine)
Clonality Polyclonal
Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN349986
Quantity 500 µg
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from human coiled-coil myosin-like BCL2-interacting protein (Beclin-1, BECN1, GT197, ATG6, VPS30) conjugated to an immunogenic carrier protein has been used as the immunogen. The antigen is homologous in rat and mouse.
Isotype IgG
Specificity Appears to be specific for Beclin-1.
Purification Protein A affinity column
Purity IgG
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. It may play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. May play a role inautophagy.
Subcellular location: Cytoplasm. Golgi apparatus membrane, Peripheral membrane protein. Note: Expressed in dendrites and cell bodies of cerebellar Purkinje cells
Tissue specificity: Ubiquitous Also known as: Beclin-1, BECN1, GT197, ATG6, VPS30, beclin1.
UniProt Q14457
Research Area Autophagy
Application Notes IHC, WB. Use at a concentration of 10-50 µg/ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Rommens, Durocher, McArthur et al.: "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21." in: Genomics, Vol. 28, Issue 3, pp. 530-42, 1996 (PubMed).

Aita, Liang, Murty et al.: "Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21." in: Genomics, Vol. 59, Issue 1, pp. 59-65, 1999 (PubMed).

Liang, Jackson, Seaman et al.: "Induction of autophagy and inhibition of tumorigenesis by beclin 1." in: Nature, Vol. 402, Issue 6762, pp. 672-6, 2000 (PubMed).

Kihara, Kabeya, Ohsumi et al.: "Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network." in: EMBO reports, Vol. 2, Issue 4, pp. 330-5, 2001 (PubMed).

Koneri, Goi, Hirono et al.: "Beclin 1 gene inhibits tumor growth in colon cancer cell lines." in: Anticancer research, Vol. 27, Issue 3B, pp. 1453-7, 2007 (PubMed).

Lee, Jeong, Yoo et al.: "Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 115, Issue 12, pp. 1357-63, 2008 (PubMed).