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Details for Product No. ABIN350080

Activity-Regulated Cytoskeleton-Associated Protein (Arc) antibody

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Antigen
Synonyms Arg3.1, rg3.1, ARG3.1, ARC, arg3.1
Reactivity
»Alternatives Human
Host
»Alternatives Sheep
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350080
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen Synthetic peptides from human Arg3.1 (ARC) was used as the immunogen. The antigen is homologous in rat and mouse.
Isotype IgG
Specificity Appears to be specific for Arg3.1/ARC.
Purity IgG
Alternative Name Arg3.1 (ARC)
Background Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
Subcellular location: Cytoplasm, cytoskeleton. Endosome. Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail. Also known as: Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, Arg3.1/ARC,.
UniProt Q7LC44
Application Notes IHC, WB (confirmed by recombinant protein).. Use at a concentration of 10-50 µg/ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Chowdhury, Shepherd, Okuno et al.: "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking." in: Neuron, Vol. 52, Issue 3, pp. 445-59, 2006 (PubMed).

Rial Verde, Lee-Osbourne, Worley et al.: "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission." in: Neuron, Vol. 52, Issue 3, pp. 461-74, 2006 (PubMed).

Shepherd, Rumbaugh, Wu et al.: "Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors." in: Neuron, Vol. 52, Issue 3, pp. 475-84, 2006 (PubMed).

Tan, Ruettiger, Panford-Walsh et al.: "Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma." in: Neuroscience, Vol. 145, Issue 2, pp. 715-26, 2007 (PubMed).

Alternatives for antigen "Activity-Regulated Cytoskeleton-Associated Protein (Arc)", type "Antibodies"
Hosts (7), (2), (1)
Reactivities (10), (4), (3)
Applications (9), (5), (3), (1), (1), (1), (1), (1), (1)
Epitopes (2), (1), (1)
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