Activity-Regulated Cytoskeleton-Associated Protein (Arc) antibody

Details for Product No. ABIN350080
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Antigen
Synonyms ARC, arg3.1, Arc3.1, C86064, mArc, Arg3.1, rg3.1, ARG3.1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(8), (4), (4)
Host
Sheep
(7), (1), (1)
Clonality
Polyclonal
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(8), (5), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 500 μg
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Catalog No. ABIN350080
454.67 $
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Immunogen A synthetic peptide from human Arg3.1 (ARC) conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Isotype IgG
Specificity Specific for Arg3.1/ARC.
Alternative Name Arg3.1 (ARC)
Background Function: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
Subcellular location: Cytoplasm, cytoskeleton. Endosome. Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail. Also known as: Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, Arg3.1/ARC,.
Application Notes Use at a concentration of 10-50 µg/ml.
The optimal working concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Chowdhury, Shepherd, Okuno et al.: "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking." in: Neuron, Vol. 52, Issue 3, pp. 445-59, 2006 (PubMed).

Rial Verde, Lee-Osbourne, Worley et al.: "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission." in: Neuron, Vol. 52, Issue 3, pp. 461-74, 2006 (PubMed).

Shepherd, Rumbaugh, Wu et al.: "Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors." in: Neuron, Vol. 52, Issue 3, pp. 475-84, 2006 (PubMed).

Tan, Ruettiger, Panford-Walsh et al.: "Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma." in: Neuroscience, Vol. 145, Issue 2, pp. 715-26, 2007 (PubMed).

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