Activity-Regulated Cytoskeleton-Associated Protein (Arc) antibody

Antigen: Activity-Regulated Cytoskeleton-Associated Protein (Arc)

Synonyms: Arg3.1, KIAA0278, rg3.1, ARG3.1, ARC, arg3.1, Arc3.1, C86064

Clonality: Polyclonal

Host: Sheep

Reactivity: Please enquire

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350080

Additional Information

Alternative name: Arg3.1 (ARC)

UniProt: Q7LC44

Immunogen: Synthetic peptides from human Arg3.1 (ARC) was used as the immunogen. The antigen is homologous in rat and mouse.

Format: Lyophilized

Isotype: IgG

Description: FUNCTION: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Endosome. Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note=Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail. Also known as: Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, Arg3.1/ARC,.

Specificity: Appears to be specific for Arg3.1/ARC.

Application Details

Application Notes: IHC, WB (confirmed by recombinant protein).. Use at a concentration of 10-50 µg/ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications.

Purity: IgG

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Chowdhury, Shepherd, Okuno et al.: "Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking." in: Neuron, Vol. 52, Issue 3, pp. 445-59, 2006 (PubMed).

Rial Verde, Lee-Osbourne, Worley et al.: "Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission." in: Neuron, Vol. 52, Issue 3, pp. 461-74, 2006 (PubMed).

Shepherd, Rumbaugh, Wu et al.: "Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors." in: Neuron, Vol. 52, Issue 3, pp. 475-84, 2006 (PubMed).

Tan, Ruettiger, Panford-Walsh et al.: "Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma." in: Neuroscience, Vol. 145, Issue 2, pp. 715-26, 2007 (PubMed).