» Antibodies » CACNA1F Antibody Abstract » anti-Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F) (Cytop...

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Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F) (Cytoplasmic Domain) antibody

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Antigen
Synonyms	JM8, OA2, AIED, COD3, COD4, JMC8, CORDX, CSNB2, CORDX3, CSNB2A, CSNBX2, Cav1.4, A930034B14, Sfc17, nerg1, nob2, CACNA1F
Epitope	Alternatives Cytoplasmic Domain (2)
Reactivity	Alternatives Human (20), (17), (17)
Host	Alternatives Rabbit (19), (1)
Clonality	Polyclonal
Conjugate	Alternatives Un-conjugated (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application	Alternatives Immunohistochemistry (IHC), Western Blotting (WB) (15), (6), (4), (4), (3), (1), (1)
	5 references available

Catalog no.	ABIN350143
Quantity	500 µg
Price	454.67 $ Plus shipping costs $45.00

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Availability	Will be delivered in 7 to 8 Business Days

Product details

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Target Details

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Alternative Name	CACNA1F (Cav1.4)
Background	Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Subcellular location: Membrane; Multi-pass membrane protein. Also known as: Voltage-gated calcium channel subunit alpha Cav1.4, Voltage-dependent L-type calcium channel subunit alpha-1F, CACNAF1.
UniProt	O60840

Application Details

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Handling

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References

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Strom, Nyakatura, Apfelstedt-Sylla et al.: "An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness." in: Nature genetics, Vol. 19, Issue 3, pp. 260-3, 1998 (PubMed).

Wutz, Sauer, Zrenner et al.: "Thirty distinct CACNA1F mutations in 33 families with incomplete type of XLCSNB and Cacna1f expression profiling in mouse retina." in: European journal of human genetics : EJHG, Vol. 10, Issue 8, pp. 449-56, 2002 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Hemara-Wahanui, Berjukow, Hope et al.: "A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of Cav1.4 channel activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 21, pp. 7553-8, 2005 (PubMed).

Jalkanen, Bech-Hansen, Tobias et al.: "A novel CACNA1F gene mutation causes Aland Island eye disease." in: Investigative ophthalmology & visual science, Vol. 48, Issue 6, pp. 2498-502, 2007 (PubMed).

Alternatives

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Alternatives for antigen "Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F)", type "Antibodies"

Immunogen	A synthetic peptide from a cytoplasmic domain of human CACNA1F (Cav1.4) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype	IgG
Specificity	Appears to be specific for CACNA1F.
Purity	IgG

Application Notes	IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.
Restrictions	For Research Use only

Format	Lyophilized
Storage	-20 °C

Hosts	(19), (1)
Reactivities	(20), (17), (17)
Applications	(15), (6), (4), (4), (3), (1), (1)
Conjugates	(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes	(2)