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Details for Product No. ABIN350143

Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F) (Cytoplasmic Domain) antibody

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Antigen
Synonyms AIED, COD3, COD4, CORDX, CORDX3, CSNB2, CSNB2A, CSNBX2, Cav1.4, Cav1.4alpha1, JM8, JMC8, OA2, A930034B14, Sfc17, nerg1, nob2, CACNA1F
Epitope
»Alternatives Cytoplasmic Domain
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350143
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen A synthetic peptide from a cytoplasmic domain of human CACNA1F (Cav1.4) conjugated to an immunogenic carrier protein was used as the immunogen.
Isotype IgG
Specificity Appears to be specific for CACNA1F.
Purity IgG

Target Details

Application Details Handling References Alternatives back to top
Alternative Name CACNA1F (Cav1.4)
Background Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
Subcellular location: Membrane, Multi-pass membrane protein. Also known as: Voltage-gated calcium channel subunit alpha Cav1.4, Voltage-dependent L-type calcium channel subunit alpha-1F, CACNAF1.
UniProt O60840

Application Details

Target Details Handling References Alternatives back to top
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Format Lyophilized
Storage -20 °C

References

Target Details Application Details Handling Alternatives back to top
Strom, Nyakatura, Apfelstedt-Sylla et al.: "An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness." in: Nature genetics, Vol. 19, Issue 3, pp. 260-3, 1998 (PubMed).

Wutz, Sauer, Zrenner et al.: "Thirty distinct CACNA1F mutations in 33 families with incomplete type of XLCSNB and Cacna1f expression profiling in mouse retina." in: European journal of human genetics : EJHG, Vol. 10, Issue 8, pp. 449-56, 2002 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Hemara-Wahanui, Berjukow, Hope et al.: "A CACNA1F mutation identified in an X-linked retinal disorder shifts the voltage dependence of Cav1.4 channel activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 21, pp. 7553-8, 2005 (PubMed).

Jalkanen, Bech-Hansen, Tobias et al.: "A novel CACNA1F gene mutation causes Aland Island eye disease." in: Investigative ophthalmology & visual science, Vol. 48, Issue 6, pp. 2498-502, 2007 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Calcium Channel, Voltage-Dependent, L Type, alpha 1F Subunit (CACNA1F)", type "Antibodies"
Hosts (20), (4)
Reactivities (24), (17), (17), (17), (17)
Applications (15), (10), (10), (7), (4), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2)
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