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Details for Product No. ABIN350153

Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 3 (CACNA2D3) (Internal Region) antibody

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Antigen
Synonyms HSA272268, Cacnad3
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN350153
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of human CACNA2D3 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is identical in mouse and rat.
Isotype IgG
Specificity Appears to be specific for CACNA2D3.
Purity IgG
Alternative Name CACNA2D3
Background Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G).
Subcellular location: Membrane, Single-pass type I membrane protein
Miscellaneous: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-3, Voltage-gated calcium channel subunit alpha-2/delta-3.
UniProt Q8IZS8
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Hanke, Bugert, Chudek et al.: "Cloning a calcium channel alpha2delta-3 subunit gene from a putative tumor suppressor gene region at chromosome 3p21.1 in conventional renal cell carcinoma." in: Gene, Vol. 264, Issue 1, pp. 69-75, 2001 (PubMed).

Gong, Hang, Kohler et al.: "Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes." in: The Journal of membrane biology, Vol. 184, Issue 1, pp. 35-43, 2001 (PubMed).

Qin, Yagel, Momplaisir et al.: "Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit." in: Molecular pharmacology, Vol. 62, Issue 3, pp. 485-96, 2002 (PubMed).

Alternatives for antigen "Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 3 (CACNA2D3)", type "Antibodies"
Hosts (8), (1)
Reactivities (8), (2), (2)
Applications (9), (4), (2), (2), (2), (1), (1)
Epitopes (4), (3), (2)
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