Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 3 (CACNA2D3) (Internal Region) antibody

Antigen: Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 3 (CACNA2D3)

Synonyms: HSA272268

Binding Site: Internal Region

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350153

Additional Information

Alternative name: CACNA2D3

UniProt: Q8IZS8

Immunogen: A synthetic peptide from the internal region of human CACNA2D3 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is identical in mouse and rat.

Format: Lyophilized

Isotype: IgG

Description: FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G). Subcellular location: Membrane; Single-pass type I membrane protein Miscellaneous: In contrast to CACNA2D1 and CACNA2D2, it does not bind gabapentin, an antiepileptic drug. Also known as: Voltage-dependent calcium channel subunit alpha-2/delta-3, Voltage-gated calcium channel subunit alpha-2/delta-3.

Specificity: Appears to be specific for CACNA2D3.

Application Details

Application Notes: IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Purity: IgG

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Hanke, Bugert, Chudek et al.: "Cloning a calcium channel alpha2delta-3 subunit gene from a putative tumor suppressor gene region at chromosome 3p21.1 in conventional renal cell carcinoma." in: Gene, Vol. 264, Issue 1, pp. 69-75, 2001 (PubMed).

Gong, Hang, Kohler et al.: "Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes." in: The Journal of membrane biology, Vol. 184, Issue 1, pp. 35-43, 2001 (PubMed).

Qin, Yagel, Momplaisir et al.: "Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit." in: Molecular pharmacology, Vol. 62, Issue 3, pp. 485-96, 2002 (PubMed).