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Details for Product No. ABIN350161

CACNB4 (CACB4) (C-Term) antibody

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»Alternatives C-Term
»Alternatives Human, Rat (Rattus), Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN350161
Quantity 500 µg
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the c-terminal region of human CACNB4 (CACB4, Voltage dependent L-type calcium channel subunit beta-4) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in many species including mouse and rat.
Isotype IgG
Specificity Appears to be specific for CACNB4.
Purity IgG
Background Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB4 are associated with susceptibility to idiopathic generalized epilepsy (IGE). IGE is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CACNB4 are a cause of juvenile myoclonic epilepsy (EJM). EJM is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
Tissue specificity: Expressed predominantly in the cerebellum and kidney. Also known as: CACB4, Voltage-dependent L-type calcium channel subunit beta-4, Calcium channel voltage-dependent subunit beta 4.
UniProt O00305
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Taviaux, Williams, Harpold et al.: "Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23." in: Human genetics, Vol. 100, Issue 2, pp. 151-4, 1997 (PubMed).

Escayg, Jones, Kearney et al.: "Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic." in: Genomics, Vol. 50, Issue 1, pp. 14-22, 1999 (PubMed).

Escayg, De Waard, Lee et al.: "Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia." in: American journal of human genetics, Vol. 66, Issue 5, pp. 1531-9, 2000 (PubMed).

Helton, Horne: "Alternative splicing of the beta 4 subunit has alpha1 subunit subtype-specific effects on Ca2+ channel gating." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 5, pp. 1573-82, 2002 (PubMed).

Alternatives for antigen "CACNB4 (CACB4)", type "Antibodies"
Hosts (1)
Reactivities (1), (1), (1)
Applications (1), (1)
Epitopes (1)