You are viewing an incomplete version of our website. Please click to reload the website as full version.

Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4) (C-Term) antibody

Details for Product No. ABIN350161, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms CACNB4, CAB4, CACNLB4, EA5, EIG9, EJM, EJM4, EJM6, 3110038O15Rik, Cchb4, lethargic, lh
(36), (30), (8), (3), (2), (2), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(71), (47), (30), (18), (6), (4), (3), (3), (2), (2), (2), (2), (2), (1)
(43), (32), (15)
(4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Immunohistochemistry (IHC), Western Blotting (WB)
(88), (37), (35), (34), (32), (20), (1), (1)
Pubmed 4 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 500 μg
Shipping to United States ( )
Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the c-terminal region of human CACNB4 (CACB4, Voltage dependent L-type calcium channel subunit beta-4) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in many species including mouse and rat.
Isotype IgG
Specificity Specific for CACNB4.
Alternative Name CACNB4 (CACNB4 Antibody Abstract)
Background Function: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB4 are associated with susceptibility to idiopathic generalized epilepsy (IGE). IGE is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CACNB4 are a cause of juvenile myoclonic epilepsy (EJM). EJM is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue.
Tissue specificity: Expressed predominantly in the cerebellum and kidney. Also known as: CACB4, Voltage-dependent L-type calcium channel subunit beta-4, Calcium channel voltage-dependent subunit beta 4.
Research Area Signaling
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
Background publications Helton, Horne: "Alternative splicing of the beta 4 subunit has alpha1 subunit subtype-specific effects on Ca2+ channel gating." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 5, pp. 1573-82, 2002 (PubMed).

Escayg, De Waard, Lee et al.: "Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia." in: American journal of human genetics, Vol. 66, Issue 5, pp. 1531-9, 2000 (PubMed).

Escayg, Jones, Kearney et al.: "Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic." in: Genomics, Vol. 50, Issue 1, pp. 14-22, 1999 (PubMed).

Taviaux, Williams, Harpold et al.: "Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23." in: Human genetics, Vol. 100, Issue 2, pp. 151-4, 1997 (PubMed).

Catalog No. ABIN350161
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)