Regulator of Calcineurin 1 (RCAN1) (Internal Region) antibody

Details for Product No. ABIN350175
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Antigen
Synonyms
RCAN1, dscr1, rcan1, wu:fr92c05, MGC53636, csp1, dsc1, rcn1, mcip1, adapt78, MGC69428, CDHF1, DG2/DG3, DSCR1, ADAPT78, CSP1, DSC1, MCIP1, RCN1, 2410048A02Rik, AA408855, AI429645, AL024459, AV028423, A ... show more
RCAN1, dscr1, rcan1, wu:fr92c05, MGC53636, csp1, dsc1, rcn1, mcip1, adapt78, MGC69428, CDHF1, DG2/DG3, DSCR1, ADAPT78, CSP1, DSC1, MCIP1, RCN1, 2410048A02Rik, AA408855, AI429645, AL024459, AV028423, Adapt78, CALP1L, Dscr1, Mcip1 show less
Epitope
Internal Region
(22), (12), (11), (6), (6), (6), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus), Mouse (Murine)
(89), (33), (32), (2), (2), (1), (1)
Host
Rabbit
(81), (6), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(80), (37), (14), (11), (10), (6), (4), (3), (2), (1)
Pubmed 5 references available
Quantity 500 μg
Options
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Catalog No. ABIN350175
454.67 $
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Immunogen A synthetic peptide from the internal region of human Calcipressin 1 (RCAN1, MCIP1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 97% identity with rat and mouse sequence.
Isotype IgG
Specificity Specific for RCAN1.
Alternative Name RCAN1
Background Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Tissue specificity: Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Also known as: Calcipressin-1, Calcipressin1, Regulator of calcineurin 1, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Adapt78, ADAPT78, CSP1, DSC1, DSCR1, RCAN1.
Application Notes A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date 12 months
General Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Genescua, Aubareda, Fuentes et al.: "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life." in: The Biochemical journal, Vol. 374, Issue Pt 2, pp. 567-75, 2003 (PubMed).

Hattori, Fujiyama, Taylor et al.: "The DNA sequence of human chromosome 21." in: Nature, Vol. 405, Issue 6784, pp. 311-9, 2000 (PubMed).

Fuentes, Pritchard, Estivill: "Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene." in: Genomics, Vol. 44, Issue 3, pp. 358-61, 1997 (PubMed).

Fuentes, Pritchard, Planas et al.: "A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart." in: Human molecular genetics, Vol. 4, Issue 10, pp. 1935-44, 1996 (PubMed).

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