Regulator of Calcineurin 1 (RCAN1) (Internal Region) antibody

Antigen: Regulator of Calcineurin 1 (RCAN1)

Synonyms: RCAN1, dscr1, wu:fr92c05, csp1, dsc1, mcip1, adapt78, MGC68988, MGC53636, LOC443255, DSCR1, rcn1, MGC69428, CSP1, DSC1, RCN1, MCIP1, ADAPT78, Dscr1, CALP1L, Adapt78, AA408855, AI429645, AL024459, AV028423, 2410048A02Rik, Mcip1, MGC128596, DKFZp469I0324

Binding Site: Internal Region

Clonality: Polyclonal

Host: Rabbit

Reactivity: Please enquire

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Catalog no.: ABIN350175

Additional Information

Alternative name: Calcipressin 1 (RCAN1, MCIP1)

UniProt: P53805

Immunogen: A synthetic peptide from the internal part of human Calcipressin 1 (RCAN1, MCIP1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 97% identity with rat and mouse sequence.

Format: Lyophilized

Description: Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Tissue specificity: Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Also known as: Calcipressin-1, Calcipressin1, Regulator of calcineurin 1, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Adapt78, ADAPT78, CSP1, DSC1, DSCR1, RCAN1.

Specificity: Appears to be specific for RCAN1.

Synonyms: RCAN1, dscr1, wu:fr92c05, csp1, dsc1, mcip1, adapt78, MGC68988, MGC53636, LOC443255, DSCR1, rcn1, MGC69428, CSP1, DSC1, RCN1, MCIP1, ADAPT78, Dscr1, CALP1L, Adapt78, AA408855, AI429645, AL024459, AV028423, 2410048A02Rik, Mcip1, MGC128596, DKFZp469I0324

Application Details

Application Notes: IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Purity: IgG

Storage: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Restrictions: For Research Use only

Publications

Fuentes, Pritchard, Planas et al.: "A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart." in: Human molecular genetics, Vol. 4, Issue 10, pp. 1935-44, 1996 (PubMed).

Fuentes, Pritchard, Estivill: "Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene." in: Genomics, Vol. 44, Issue 3, pp. 358-61, 1997 (PubMed).

Hattori, Fujiyama, Taylor et al.: "The DNA sequence of human chromosome 21." in: Nature, Vol. 405, Issue 6784, pp. 311-9, 2000 (PubMed).

Genescua, Aubareda, Fuentes et al.: "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life." in: The Biochemical journal, Vol. 374, Issue Pt 2, pp. 567-75, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).