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Details for Product No. ABIN350175

Regulator of Calcineurin 1 (RCAN1) (Internal Region) antibody

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Antigen
Synonyms
adapt78, csp1, dsc1, dscr1, mcip1, DSCR1, RCAN1, CSP1, DSC1, RCN1, MCIP1, ADAPT78, Dscr1, CALP1L, Adapt78, AA408855, AI429645, AL024459, AV028423, 2410048A02Rik, Mcip1, rcan1, wu:fr92c05, MGC53636, rc ... show more
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human, Rat (Rattus), Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350175
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days

Product details

Target Details Application Details Handling References Alternatives back to top
Immunogen A synthetic peptide from the internal part of human Calcipressin 1 (RCAN1, MCIP1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 97% identity with rat and mouse sequence.
Specificity Appears to be specific for RCAN1.
Purity IgG

Target Details

Application Details Handling References Alternatives back to top
Alternative Name Calcipressin 1 (RCAN1, MCIP1)
Background Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Tissue specificity: Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Also known as: Calcipressin-1, Calcipressin1, Regulator of calcineurin 1, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Adapt78, ADAPT78, CSP1, DSC1, DSCR1, RCAN1.
UniProt P53805

Application Details

Target Details Handling References Alternatives back to top
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
Restrictions For Research Use only

Handling

Target Details Application Details References Alternatives back to top
Format Lyophilized
Storage -20 °C

References

Target Details Application Details Handling Alternatives back to top
Fuentes, Pritchard, Planas et al.: "A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart." in: Human molecular genetics, Vol. 4, Issue 10, pp. 1935-44, 1996 (PubMed).

Fuentes, Pritchard, Estivill: "Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene." in: Genomics, Vol. 44, Issue 3, pp. 358-61, 1997 (PubMed).

Hattori, Fujiyama, Taylor et al.: "The DNA sequence of human chromosome 21." in: Nature, Vol. 405, Issue 6784, pp. 311-9, 2000 (PubMed).

Genescua, Aubareda, Fuentes et al.: "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life." in: The Biochemical journal, Vol. 374, Issue Pt 2, pp. 567-75, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Alternatives

Target Details Application Details Handling References back to top
Alternatives for antigen "Regulator of Calcineurin 1 (RCAN1)", type "Antibodies"
Hosts (65), (7), (5)
Reactivities (72), (28), (27), (15), (12), (2), (1), (1)
Applications (64), (30), (12), (12), (10), (5), (3), (1), (1), (1)
Conjugates (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (9), (8), (6), (6), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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