Regulator of Calcineurin 1 (RCAN1) (Internal Region) antibody

Details for Product No. ABIN350175
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Antigen
Synonyms
adapt78, csp1, dsc1, dscr1, mcip1, DSCR1, RCAN1, CSP1, DSC1, RCN1, MCIP1, ADAPT78, Dscr1, CALP1L, Adapt78, AA408855, AI429645, AL024459, AV028423, 2410048A02Rik, Mcip1, rcan1, wu:fr92c05, MGC53636, rc ... show more
adapt78, csp1, dsc1, dscr1, mcip1, DSCR1, RCAN1, CSP1, DSC1, RCN1, MCIP1, ADAPT78, Dscr1, CALP1L, Adapt78, AA408855, AI429645, AL024459, AV028423, 2410048A02Rik, Mcip1, rcan1, wu:fr92c05, MGC53636, rcn1, MGC69428 show less
Epitope
Internal Region
(15), (8), (8), (6), (6), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(74), (31), (31), (14), (12), (2), (1), (1)
Host
Rabbit
(66), (7), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(66), (29), (12), (10), (10), (5), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN350175
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the internal region of human Calcipressin 1 (RCAN1, MCIP1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 97% identity with rat and mouse sequence.
Specificity Specific for CACNA2D1.
Purification IgG
Alternative Name Calcipressin 1 (RCAN1, MCIP1)
Background Function: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
Tissue specificity: Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues. Also known as: Calcipressin-1, Calcipressin1, Regulator of calcineurin 1, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, MCIP1, Adapt78, ADAPT78, CSP1, DSC1, DSCR1, RCAN1.
UniProt Q9ERS3
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
General Fuentes, Pritchard, Planas et al.: "A new human gene from the Down syndrome critical region encodes a proline-rich protein highly expressed in fetal brain and heart." in: Human molecular genetics, Vol. 4, Issue 10, pp. 1935-44, 1996 (PubMed).

Fuentes, Pritchard, Estivill: "Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene." in: Genomics, Vol. 44, Issue 3, pp. 358-61, 1997 (PubMed).

Hattori, Fujiyama, Taylor et al.: "The DNA sequence of human chromosome 21...." in: Nature, Vol. 405, Issue 6784, pp. 311-9, 2000 (PubMed).

Genescua, Aubareda, Fuentes et al.: "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life." in: The Biochemical journal, Vol. 374, Issue Pt 2, pp. 567-75, 2003 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Hosts (66), (7), (3), (1)
Reactivities (74), (31), (31), (14), (12), (2), (1), (1)
Applications (66), (29), (12), (10), (10), (5), (2), (2), (1)
Conjugates (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (8), (8), (6), (6), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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