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Pro-Hepcidin (AA 39-59) antibody

Reactivity: Mouse IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN350367
  • Target
    Pro-Hepcidin
    Binding Specificity
    AA 39-59
    Reactivity
    Mouse
    Host
    Rabbit
    Clonality
    Polyclonal
    Application
    Immunohistochemistry (IHC), Western Blotting (WB)
    Specificity
    Specific for Hepcidin.
    Cross-Reactivity
    Mouse
    Cross-Reactivity (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogen
    A synthetic peptide from AA 39-59 of pro region of mouse Hepcidin conjugated to blue carrier protein has been used as the antigen.
    Isotype
    IgG
  • Application Notes
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Mohammad, Matakidou, Robbins, Lakhal-Littleton: "The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload." in: Kidney international, Vol. 100, Issue 3, pp. 559-569, (2021) (PubMed).

  • Target
    Pro-Hepcidin
    Synonyms
    HAMP antibody, hepcidin antibody, hepcidin antimicrobial peptide antibody, hamp antibody, HAMP antibody
    Background
    FUNCTION: Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages. May also have antimicrobial activity. SUBCELLULAR LOCATION: Secreted. Tissue specificity: Highly expressed in the liver and to a much lesser extent in the heart.,Hepcidin,Hepcidin, Liver-expressed antimicrobial peptide, LEAP-1, Putative liver tumor regressor, HAMP, HEPC, LEAP1
    UniProt
    Q9EQ21
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