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Details for Product No. ABIN350766

Proteinase 3 (PRTN3) (Internal Region) antibody

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Antigen
Synonyms ACPA, AGP7, C-ANCA, CANCA, MBN, MBT, NP-4, NP4, P29, PR-3, PR3, mPR3, ela2, MGC132250
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN350766
Quantity 100 µL
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the internal region of human Pr3 (Leukocyte proteinase 3, AGP7, Myeloblastin, Wegener autoantigen) conjugated to an immunogenic carrier protein was used as the antigen.
Specificity Specific for SERCA1.
Purity IgG
Alternative Name Pr3 (Wegener autoantigen)
Background Function: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to s.
Catalytic activity: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-|-Xaa- > -Val-|-Xaa-. Also known as: Leukocyte proteinase 3, AGP7, Myeloblastin, Wegener autoantigen, PR-3, P29, C-ANCA antigen, Neutrophil proteinase 4, MBN, PRTN3, NP-4.
UniProt O14983
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
Labbaye, Musette, Cayre: "Wegener autoantigen and myeloblastin are encoded by a single mRNA." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 20, pp. 9253-6, 1991 (PubMed).

Jenne, Tschopp, Luedemann et al.: "Wegener's autoantigen decoded." in: Nature, Vol. 346, Issue 6284, pp. 520, 1990 (PubMed).

Duke-Cohan, Morimoto, Rocker et al.: "A novel form of dipeptidylpeptidase IV found in human serum. Isolation, characterization, and comparison with T lymphocyte membrane dipeptidylpeptidase IV (CD26)." in: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14107-14, 1995 (PubMed).

Fujinaga, Chernaia, Halenbeck et al.: "The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies." in: Journal of molecular biology, Vol. 261, Issue 2, pp. 267-78, 1996 (PubMed).

Grimwood, Gordon, Olsen et al.: "The DNA sequence and biology of human chromosome 19." in: Nature, Vol. 428, Issue 6982, pp. 529-35, 2004 (PubMed).

Alternatives for antigen "Proteinase 3 (PRTN3)", type "Antibodies"
Hosts (61), (46), (3), (1)
Reactivities (94), (23), (21), (1), (1), (1)
Applications (78), (64), (14), (12), (11), (10), (10), (10), (8), (5), (4), (3), (3), (2)
Conjugates (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (6), (3), (2), (2), (2), (1)
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